Results 61 to 70 of about 63,697 (228)

Vitiligo and autoimmune thyroid disorders [PDF]

, 2017
Vitiligo represents the most common cause of acquired skin, hair and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte ...
Baldini, Enke, Carbotta, Giovanni, Catania, Antonio, D'Armiento, Eleonora, Odorisio, Teresa, Persechino, Severino, Pironi, Daniele, Rendina, Roberta, Sorrenti, Salvatore, Tartaglia, Francesco, Ulisse, Salvatore   +10 more
core   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Polymerase Chain Reaction. Perturbation Theory and Machine Learning Artificial Intelligence‐Experimental Microbiome Analysis: Applications to Ancient DNA and Tree Soil Metagenomics Cases of Study

Advanced Intelligent Systems, EarlyView.
The polymerase chain reaction (PCR).Perturbation Theory and Machine Learning framework integrates perturbation theory and machine learning to classify genetic sequences, distinguishing ancient DNA from modern controls and predicting tree health from soil metagenomic data.
Jose L. Rodriguez, Estefania Ascencio, Jose M. Ageitos, Lucia Feijoo, Shan He, Amirreza Daghighi, Gerardo M. Casanola‐Martin, Cristian R. Munteanu, Santiago Rodriguez Yañez, Alejandro Pazos, Harbil Bediaga, Brenda Durand Ordiales, Raquel Esteban, Ana‐Maria Heres, Jorge Curiel Yuste, Lur Epelde, Bakhtiyor Rasulev, Tomas Gonzalez, Sonia Arrasate, Humberto González‐Diaz   +19 more
wiley   +1 more source

Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]

PeerJ, 2018
Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li, Hongyu Yang, Jun Mo, Yao Chen, Yue Wu, Chen Kang, Yuan Sun, Haopeng Sun   +7 more
doaj   +2 more sources

Synthesis and study of polyhydroxylated phenol derivatives with potential cosmetic and phytoiatric applications [PDF]

, 2013
Tyrosinase (polyphenol oxidase, E.C. 1.14.18.1) and laccase (phenol oxidase, E.C. 1.10.3.2) are multifunctional copper-containing enzymes, that are keys in melanin biosynthesis, melanisation in animals and browning in plants.
Dallocchio, Roberto, Delogu, Giovanna, Dessì, Alessandro, Dettori, Maria Antonietta, Fabbri, Davide, Fois, Xenia, Pantaleoni, Roberto Antonio, Rocchitta, Gaia Giovanna Maria, Serra, Pier Andrea   +8 more
core  

Potensi Sinamaldehid sebagai Anti Hiperpigmentasi secara In Silico

Jurnal Ilmiah Medicamento, 2021
Permasalahan kulit yang sering ditemui yaitu hiperpigmentasi yang terjadi akibat adanya sintesis melanin berlebihan yang menyebabkan penggelapan warna kulit.
Ni Made Gani Pratiwi, Ni Made Atika Saraswati, Ni Made Irma Febby Prasasti Dewi, Luh Pande Putu Tirta   +3 more
doaj  

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo. [PDF]

, 2010
BACKGROUND Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases. METHODS To identify generalized
Alain Taïeb, Alexandra J.D. Sufit, Andreas Overbeck, Anita Amadi-Myers, Anthony P. Weetman, Brand OJ, Christina M. Mailloux, David J. Gawkrodger, Dorothy C. Bennett, E. Helen Kemp, Giovanni Leone, Honda Y, Jo Lambert, Katherine Gowan, Khaled Ezzedine, Margaret R. Wallace, Mauro Picardo, Nanny van Geel, Pamela R. Fain, Paulene J. Holland, Richard A. Spritz, Saunie M. Hutton, Sheri L. Riccardi, Stanca A. Birlea, Thomas Jouary, Tripathi RK, Waerner T, Wang L, Wayne T. McCormack, Ying Jin   +29 more
core   +3 more sources

Tyrosinase-catalyzed Oxidation of Fluorophenols [PDF]

Journal of Biological Chemistry, 2002
The activity of the type 3 copper enzyme tyrosinase toward 2-, 3-, and 4-fluorophenol was studied by kinetic methods and (1)H and (19)F NMR spectroscopy. Whereas 3- and 4-fluorophenol react with tyrosinase to give products that undergo a rapid polymerization process, 2-fluorophenol is not reactive and actually acts as a competitive inhibitor in the ...
Battaini, G., Monzani, E., Casella, L., Lonardi, E., Tepper, A.W.J.W., Canters, G.W., Bubacco, L.   +6 more
openaire   +5 more sources

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni, Xinyu Luo, Xiaoying Jiang, Wenchao Chen, Renren Bai   +4 more
doaj   +1 more source