Results 41 to 50 of about 22,420 (243)

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Betalains in some species of the amaranthaceae family: A review [PDF]

, 2018
Natural pigments are largely distributed in the plant kingdom. They belong to diverse groups, with distinct biochemical pathways. Betalains with colours that range from yellow to red-violet can de divided into two main subgroups: betaxanthins and ...
Ali, Barua, Bhujbal, Bucur, Bussmann, Böhm, Clemente, Corio-Costet, Dinda, Guo, Križnic, Kumar, Liu, Malomo, Mujica, Mulinacci, Narayanan, Nidavani, Pavoković, Pietrzkowski, Popa, Ramachandran, Rehman, Rub, Salvador, Saqib, Saritha, Shao, Surse, Telagari, Vendruscolo, Yaacob   +31 more
core   +2 more sources

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]

International Journal of Molecular Sciences, 2017
Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Choi, Joonhyuck, Lee, You-Mie, Jee, Jun-Goo   +2 more
openaire   +2 more sources

Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

Journal of Chemistry, 2013
In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity.
Ramesh L. Sawant, Prashant D. Lanke, Jyoti B. Wadekar   +2 more
doaj   +1 more source

Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies. [PDF]

PLoS ONE, 2017
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to ...
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip   +7 more
doaj   +1 more source

Antifouling bastadin congeners target blue mussel phenoloxidase and complex copper(II) ions [PDF]

, 2011
Synthetically prepared congeners of spongederived bastadin derivatives such as 5,5'-dibromohemibastadin- 1 (DBHB) that suppress the settling of barnacle larvae were identified in this study as strong inhibitors of blue mussel phenoloxidase that is ...
Bayer, M., Frank, W., Hellio, Claire, Lin, W., Marechal, J-P., Proksch, P., Weber, H.   +6 more
core   +1 more source

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways

Medicines, 2019
Background: Liquiritin (LQ) and its aglycone, liquiritigenin (LQG), are major flavonoids in licorice root (Glycyrrhiza spp.). Our preliminary screening identified LQ and LQG, which promote melanin synthesis in the melanoma cells.
Takuhiro Uto, Tomoe Ohta, Akihisa Yamashita, Shunsuke Fujii, Yukihiro Shoyama   +4 more
doaj   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Bendz, Bendz, Bernhardt, Bernhardt, Calderwood, Calderwood, Carilli, Carilli, Castellino, Castellino, Davis, Davis, Elguindi, Elguindi, Farr, Farr, Fernández, Fernández, Flechtner, Flechtner, Flynn, Flynn, Fourie, Fourie, Germeroth, Germeroth, Gragerov, Gragerov, Hartl, Hartl, Ishii, Ishii, Kawakami, Kawakami, Kelley, Kelley, Knarr, Knarr, Laemmli, Laemmli, Landry, Landry, Mayer, Mayer, Mayer, Mayer, Mayer, Mayer, McCarty, McCarty, Milani, Milani, Moroi, Moroi, Multhoff, Multhoff, Noessner, Noessner, Norby, Norby, Stevens, Stevens, Suto, Suto, Takeda, Takeda, Udono, Udono, Udono, Udono, Ueda, Ueda, Visseren, Visseren, Wegele, Wegele, Wölfel, Wölfel, Zheng, Zheng, Zhu, Zhu   +81 more
core   +1 more source

From Broad-Spectrum Biocides to Quorum Sensing Disruptors and Mussel Repellents: Antifouling Profile of Alkyl Triphenylphosphonium Salts [PDF]

, 2015
30 páginas, 13 figuras, 4 tablas.-- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and
Babarro, José M. F., Fernández, José J., Lahoz, Fernando, Martín, Víctor S., Martín-Rodríguez, Alberto J., Norte, Manuel, Sansón, Marta   +6 more
core   +7 more sources

Amperometric tyrosinase based biosensor using an electrogenerated polythiophene film as an entrapment support [PDF]

, 2003
International audienceAn amperometric enzyme sensor using tyrosinase, also called polyphenol oxidase (PPO), was constructed for determination of phenolic compounds and herbicides.
Fabiano, Silvia, Tran-Minh, Canh, Védrine, Christophe   +2 more
core   +2 more sources