Results 81 to 90 of about 568,389 (237)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Design, synthesis, in vitro, and in silico assays of new 4-phenylpiperazine-coumarin-triazole-acetamide hybrids as potent tyrosinase inhibitors

European Journal of Medicinal Chemistry Reports
New derivatives 12a-r, based on the 4-phenylpiperazine-coumarin-1,2,3-triazol-acetamide hybrid scaffold, were designed and tested as tyrosinase inhibitors.
Mohammad Mahdi Aghanour Ashtiani, Somaye Karimian, Aida Iraji, Navid Dastyafteh, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mohammad Mahdavi, Peyman Salehi   +7 more
doaj   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Influence of the polyunsaturated fatty acids linoleic acid, arachidonic acid, [alpha]-linolenic acid and [gamma]-linolenic acid on melanogenesis of B16 mouse melanoma cells and normal human melanocytes [PDF]

, 2002
The influence of the polyunsaturated fatty acids (PUFA) linoleic acid, arachidonic acid, α-linolenic acid and γ-linolenic acid on pigmentation was examined using different in vitro models: monolayer cultures of B16 mouse melanoma cells, monolayer ...
Stöckli, Martin
core   +1 more source

Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum

Journal of Investigative Dermatology, 1978
Lipid fractions capable of inhibiting the dopa-tyrosinase reaction in vitro were isolated by thin-layer chromatography from submerged cultures of Pityrosporum supplemented with oleic acid or vaccenic acid. Analysis of these fractions by gas chromatography-mass spectrometry revealed the presence mainly of C(9) and C(11) dicarboxylic acids.
Nazzaro-Porro, Marcella, Passi, Siro
openaire   +2 more sources

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Tyrosinase Inhibitor and Antioxidant Activity of Seaweed Powder from Fresh and Dried Sargassum plagyophyllum [PDF]

, 2017
Sargassum plagyophyllum from Sargassaceae family contains various bioactive compounds, namelyphlorotannin which is reported as an antioxidant and tyrosinase inhibitor.
Ayun Erwina Arifianti, Anwar, Effionora, Arifianti, Ayun Erwina, Nurjanah, Nurjanah, Effionora Anwar, Nurjanah Nurjanah   +5 more
core   +1 more source

Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

Molecules, 2009
In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were ...
Giovanna Delogu, Lourdes Santana, Carmen Picciau, Gianni Podda, Elias Quezada q, Maria Joao Matos, M. Benedetta Fadda, Benedetta Era, Marcella Corda, Antonella Fais   +9 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source