Results 71 to 80 of about 706,934 (223)

Inhibition effects of Eucalyptus globules Labill. essential oil against tyrosinase

Scientific Reports
Essential oils derived from Eucalyptus globules Labill. (EGEOs) represent a significant class of bioactive metabolites with broad applications in medicinal and pharmaceutical industries. Despite their various biological activities, the potential of EGEOs
Hua Zhu, Xin Zhong
doaj   +1 more source

Sustainable and Programmable Hydrogels for Bone Regeneration: A Perspective on Green Synthesis and Precision Fabrication

SusMat, EarlyView.
The clinical translation of natural hydrogels is often hindered by a fundamental conflict. Green synthesis prioritizes biosafety through mild and non‐toxic conditions, whereas precision manufacturing demands mechanical robustness and structural fidelity.
Jiaxin Wu, Xu Wang, Hanfei Li, Xibo Pei, Hao Feng, Jian Wang   +5 more
wiley   +1 more source

Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Flavonoids are widely distributed in plants and constitute the most common polyphenolic phytoconstituents in the human diet. In this study, the in vitro inhibitory activity of 44 different flavonoids (1–44) against mushroom tyrosinase was studied, and an
Katarzyna Jakimiuk, Suat Sari, Robert Milewski, Claudiu T. Supuran, Didem Şöhretoğlu, Michał Tomczyk   +5 more
doaj   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Design, synthesis and biological evaluation of novel kojic acid triazole hybrids as tyrosinase inhibitors and antibrowning agents

Scientific Reports
In this study, two series of kojic acid triazole hybrids, namely 6a–6p and 13a–13t, were designed and synthesized. Subsequently, their biological activities including anti-tyrosinase, antioxidant, and as anti-browning effects were investigated.
Dan Liu, Junyuan Tang, Sheng Tao, Dahan Wang, Jinbing Liu   +4 more
doaj   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum

Journal of Investigative Dermatology, 1978
Lipid fractions capable of inhibiting the dopa-tyrosinase reaction in vitro were isolated by thin-layer chromatography from submerged cultures of Pityrosporum supplemented with oleic acid or vaccenic acid. Analysis of these fractions by gas chromatography-mass spectrometry revealed the presence mainly of C(9) and C(11) dicarboxylic acids.
Nazzaro-Porro, Marcella, Passi, Siro
openaire   +2 more sources

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Design, synthesis, in vitro, and in silico assays of new 4-phenylpiperazine-coumarin-triazole-acetamide hybrids as potent tyrosinase inhibitors

European Journal of Medicinal Chemistry Reports
New derivatives 12a-r, based on the 4-phenylpiperazine-coumarin-1,2,3-triazol-acetamide hybrid scaffold, were designed and tested as tyrosinase inhibitors.
Mohammad Mahdi Aghanour Ashtiani, Somaye Karimian, Aida Iraji, Navid Dastyafteh, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mohammad Mahdavi, Peyman Salehi   +7 more
doaj   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source