Results 211 to 220 of about 21,627 (244)

New saccharin derivatives as tyrosinase inhibitors

Bioorganic & Medicinal Chemistry, 2012
A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme with 6.85% yield was achieved by using a Sepharose 4B-l-tyrosine-p-amino benzoic acid affinity column.
Gençer, Nahit, Demir, Dudu, Sönmez, Fatih, Küçükislamoğlu, Mustafa   +3 more
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Thiosemicarbazones as inhibitors of tyrosinase enzyme

Bioorganic & Medicinal Chemistry Letters, 2017
In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A, Soares, Mariana A, Almeida, Carla, Marins-Goulart, Otávio A, Chaves, Aurea, Echevarria, Márcia C C, de Oliveira   +5 more
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Tyrosinase Inhibitors from Artocarpus gomezianus

Planta Medica, 2000
Eight compounds including, phenyl-beta-naphthylamine (1), isocyclomorusin (2), cycloartocarpin (3), artocarpin (4), norartocarpetin (5), cudraflavone C (6), albanin A (7), and resveratrol (8) were isolated from the roots of Artocarpus gomezianus. Compounds 5 and 8 exhibited potent tyrosinase inhibitory activity.
K, Likhitwitayawuid, B, Sritularak, W, De-Eknamkul   +2 more
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Biomedical applications of tyrosinases and tyrosinase inhibitors

Tyrosinase is involved in several human diseases, among which hypopigmentation and depigmentation conditions (vitiligo, idiopathic guttate hypomelanosis, pityriasis versicolor, pityriasis alba) and hyperpigmentations (melasma, lentigines, post-inflammatory and periorbital hyperpigmentation, cervical idiopathic poikiloderma and acanthosis nigricans ...
Luigi, Pisano, Martina, Turco, Claudiu T, Supuran   +2 more
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New Tyrosinase Inhibitors, (+)-Catechin−Aldehyde Polycondensates

Biomacromolecules, 2004
In this study, new tyrosinase inhibitors, (+)-catechin-aldehyde polycondensates, have been developed. Tyrosinase is a copper-containing enzyme that catalyzes the hydroxylation of a monophenol (monophenolase activity) and the oxidation of an o-diphenol (diphenolase activity).
Young-Jin, Kim, Joo Eun, Chung, Motoichi, Kurisawa, Hiroshi, Uyama, Shiro, Kobayashi   +4 more
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Bacterial tyrosinases and their inhibitors

Bacterial tyrosinase is a copper-containing metalloenzyme with diverse physio-chemical properties, that have been identified in various bacterial strains, including actinobacteria and proteobacteria. Tyrosinases are responsible for the rate-limiting catalytic steps in melanin biosynthesis and enzymatic browning.
Ali, Irfan, Yousef A, Bin Jardan, Laila, Rubab, Huma, Hameed, Ameer Fawad, Zahoor, Claudiu T, Supuran   +5 more
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Computational studies of tyrosinase inhibitors

Computational studies have significantly advanced the understanding of tyrosinase (TYR) function, mechanism, and inhibition, accelerating the development of more effective and selective inhibitors. This chapter provides an overview of in silico studies on TYR inhibitors, emphasizing key inhibitory chemotypes and the main residues involved in ligand ...
Alessandro, Bonardi, Paola, Gratteri
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Natural products as tyrosinase inhibitors

Tyrosinase is a crucial copper-containing enzyme involved in the production of melanin. Melasma, age spots, and freckles are examples of hyperpigmentation diseases caused by excess production of melanin. Inhibiting tyrosinase activity is a crucial method for treating these disorders along with various applications such as cosmetics, food technology ...
Aslınur, Doğan, Suleyman, Akocak
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Potent tyrosinase inhibitors fromTrifolium balansae

Natural Product Research, 2006
Trifolium balansae (Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T.balansae. The structures of the isolates were determined by 1D and 2D NMR techniques and MS spectroscopy. Compounds 1-5
Sabudak, Temine, Khan, Mahmut Tareq Hassan, Choudhary, M. Iqbal, Oksuz, Sevil   +3 more
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Drug design of tyrosinase inhibitors

This copper-containing enzyme catalyzes the rate-limiting step for the melanin skin pigment bioproduction. Tyrosinase inhibitors can be exploited as skin whitening agents and food preservatives, opening new scenarios in food, cosmetics, agriculture and medicine.
Melfi F., Carradori S., Granese A., Osmanovic A., Campestre C.   +4 more
openaire   +2 more sources