Results 61 to 70 of about 207,078 (211)

Protein tyrosine nitration in mast cells [PDF]

, 2011
Nitric oxide (NO) is a short-lived free radical that plays a critical role in the regulation of cellular signalling. Mast cell (MC) derived NO and exogenous NO regulate MC activities including the inhibition of MC degranulation.
Sekar, Yokananth
core   +1 more source

Biological Oxidations and Nitrations Promoted by the Hemin–Aβ₁₆ Complex

Antioxidants, 2023
Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer’s disease. Hemin contributes to the development of the disease as it possesses redox properties and its level increases in pathological conditions or traumatic brain
Silvia De Caro, Giulia De Soricellis, Simone Dell’Acqua, Enrico Monzani, Stefania Nicolis   +4 more
doaj   +1 more source

Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration [PDF]

, 2007
Proteins are targets of reactive nitrogen species such as peroxynitrite and nitrogen dioxide. Among the various amino acids in proteins, tyrosine and tryptophan residues are especially susceptible to attack by reactive nitrogen species. On the other hand,
Cai, H., Yan-Mei Li, Dian-Dou Xu, Lei, P., Li, Y. M., Xiao-Yang Su, Zhao, Y. F., 赵玉芬, Hui Cai, Shi, W. Q., Wei-Qun Shi, Yu-Fen Zhao, Su, X. Y., Peng Lei, Xu, D. D.   +14 more
core   +1 more source

Proteomic approaches to analyze protein tyrosine nitration. [PDF]

Antioxid Redox Signal, 2013
The conversion of protein-bound Tyr residues to 3-nitrotyrosine (3NY) can occur during nitrative stress and has been correlated to aging and many disease states. Proteomic analysis of this post-translational modification, using mass spectrometry-based techniques, is crucial for understanding its potential role in pathological and physiological ...
Feeney MB, Schöneich C.
europepmc   +4 more sources

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects [PDF]

Antioxidants & Redox Signaling, 2017
"Nitroproteomic" is under active development, as 3-nitrotyrosine in proteins constitutes a footprint left by the reactions of nitric oxide-derived oxidants that are usually associated to oxidative stress conditions. Moreover, protein tyrosine nitration can cause structural and functional changes, which may be of pathophysiological relevance for human ...
Batthyany, Carlos, S, Bartesaghi, M, Mastrogiovanni, Lima, Analía, V, Demicheli, Radi, Rafael   +5 more
openaire   +2 more sources

Mechanisms of Peroxynitrite-Mediated Nitration of Tyrosine

, 2016
The mechanisms of tyrosine nitration by peroxynitrous acid or nitrosoperoxycarbonate were investigated with the CBS-QB3 method. Either the protonation of peroxynitrite or a reaction with carbon dioxide gives a reactive peroxide intermediate ...
Hakan Gunaydin (177019), K. N. Houk (1247004)   +1 more
core   +1 more source

Inhibition of the Soluble Epoxide Hydrolase by Tyrosine Nitration [PDF]

Journal of Biological Chemistry, 2009
Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human sEH contains two tyrosine residues (Tyr(383) and Tyr(466)) that are theoretically crucial for enzymatic ...
Barbosa Sicard, Eduardo, Frömel, Timo, Keserü, Benjamin, Brandes, Ralf, Morisseau, Christophe, Hammock, Bruce D., Braun, Thomas, Krüger, Marcus, Fleming, Ingrid   +8 more
openaire   +3 more sources

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source