Results 71 to 80 of about 8,951 (194)

Resveratrol relieves myocardial ischemia–reperfusion injury through inhibiting AKT nitration modification

Redox Report
Objective The aim of this study was to clarify whether Protein kinase B (PKB)/AKT is nitrated in myocardial ischemia and reperfusion injury (MIRI) resveratrol (RSV)’s protective effect during this process.Methods We blocked blood flow of the left ...
Lei Li, Jiantao Wang, Dandan Zhang, Li Deng, Xudong Zhao, Chunqing Wang, Xianliang Yan, Shuqun Hu   +7 more
doaj   +1 more source

ANSID: a Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites

Frontiers in Chemistry, 2016
Nitration of tyrosine and other aromatic amino acid residues in proteins occurs in the setting of inflammatory, neurodegenerative and cardiovascular diseases – importantly, this modification has been implicated in the pathogenesis of diverse diseases and
Tal eNuriel, Tal eNuriel, Julia eWhitehouse, Yuliang eMa, Emily eMercer, Emily eMercer, Neil eBrown, Steven S Gross   +7 more
doaj   +1 more source

Nitric oxide, oxidants, and protein tyrosine nitration [PDF]

Proceedings of the National Academy of Sciences, 2004
The occurrence of protein tyrosine nitration under disease conditions is now firmly established and represents a shift from the signal transducing physiological actions of • NO to oxidative and potentially pathogenic pathways.
openaire   +2 more sources

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Protein Nitration in Patients with Mitochondrial Diseases

Antioxidants
Mitochondrial diseases are complex disorders caused by nuclear or mitochondrial DNA mutations, leading to oxidative phosphorylation deficiency and excessive production of reactive oxygen species (ROS).
Jomênica B. Livramento, Gabriela S. Rodrigues, Jean Faber, Luis A. de Souza Filho, Felipo V. Moura, Camila D. S. Barros, Wladimir B. V. R. Pinto, Beny Schmidt, Acary S. B. Oliveira, Beatriz H. Kiyomoto, Célia H. Tengan   +10 more
doaj   +1 more source

Role of nitrite, urate and pepsin in the gastroprotective effects of saliva

Redox Biology, 2016
Dietary nitrate is now recognized as an alternative substrate for nitric oxide (•NO) production in the gut. This novel pathway implies the sequential reduction of nitrate to nitrite, •NO and other bioactive nitrogen oxides but the physiological relevance
Bárbara S. Rocha, Jon O Lundberg, Rafael Radi, João Laranjinha   +3 more
doaj   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Root Order Dependent Changes in Fine‐Root Substrate and Soil Environment Regulate Soil Organic Nitrogen Fractions Under Acid Rain and Nitrogen Deposition

Land Degradation &Development, EarlyView.
ABSTRACT Acid rain and nitrogen deposition are important environmental stressors affecting soil nitrogen cycling in subtropical forests, whereas fine‐root decomposition represents a major pathway for soil organic nitrogen (SON) input and transformation.
Xiongfei Zhang, Xingyu Zhang, Jinchi Zhang, Jialei Ren, Chong Li, Hui Nie, Jingyi Zeng, Xuanran Yu, Jie Lin, Tingyu Sun, Xin Liu   +10 more
wiley   +1 more source

Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications

Redox Biology, 2019
Laminin is a major protein of the basement membrane (BM), a specialized extracellular matrix (ECM) of the artery wall. The potent oxidizing and nitrating agent peroxynitrous acid (ONOOH) is formed at sites of inflammation, and data implicate ONOOH in ECM
Lasse G. Lorentzen, Christine Y. Chuang, Adelina Rogowska-Wrzesinska, Michael J. Davies   +3 more
doaj   +1 more source