Results 71 to 80 of about 207,078 (211)

DeepNitro: Prediction of Protein Nitration and Nitrosylation Sites by Deep Learning

Genomics, Proteomics & Bioinformatics, 2018
Protein nitration and nitrosylation are essential post-translational modifications (PTMs) involved in many fundamental cellular processes. Recent studies have revealed that excessive levels of nitration and nitrosylation in some critical proteins are ...
Yubin Xie, Xiaotong Luo, Yupeng Li, Li Chen, Wenbin Ma, Junjiu Huang, Jun Cui, Yong Zhao, Yu Xue, Zhixiang Zuo, Jian Ren   +10 more
doaj   +1 more source

Bio‐Derived Nanophotonic Hybrids Enabling Reconfigurable Upconversion for Multilevel Optical Encryption

Laser &Photonics Reviews, EarlyView.
A dual‐gated nanophotonic platform integrates lanthanide‐doped upconversion nanoparticles with a stimuli‐responsive silk–zirconia photonic crystal to enable multilevel optical encryption. Resonant photonic coupling allows hydration‐dependent modulation of visible emission under near‐infrared excitation, achieving reversible switching between decoy and ...
Taehoon Kim, Seohan Yun, Fiorenzo G. Omenetto, Junyong Park   +3 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Nitration in inert fluids [PDF]

, 2000
Nitration in Inert Fluids Traditional methods of nitration have several disadvantages including the environmental problem of disposal of the spent acid.
Gibbons, Linda Maria
core  

Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. [PDF]

PLoS ONE, 2010
It is believed that the endotoxin lipopolysaccharide (LPS) is implicated in the metabolic perturbations associated with both sepsis and obesity (metabolic endotoxemia).
Geneviève Pilon, Alexandre Charbonneau, Phillip J White, Patrice Dallaire, Mylène Perreault, Sonia Kapur, André Marette   +6 more
doaj   +1 more source

Magnetothermal‐responsive drug release bone cement based on EGFR‐mutated lung cancer bone metastases

VIEW, EarlyView.
A novel magnetothermal‐responsive bone cement was developed by integrating PMMA/CPC/Osimertinib matrix with Fe3O4@SiO2@Zol nanomaterials. This dual‐drug system achieves controlled release, combining excellent mechanical properties with potent anti‐tumor activity and bone regulation for treating EGFR‐mutated LC‐BoM.
Kandi Xu, Kai Li, Hao Wang, Lishu Zhao, Xinyue Liu, Yujin Liu, Li Ye, Wengang Zhang, Zhimin Chen, Xuyang Chen, Yujie Li, Qianqian Zhang, Wencheng Zhao, Xuebin Zheng, Yu Chen, Yayi He   +15 more
wiley   +1 more source

A Proteomic Study of Protein Tyrosine Nitration [PDF]

, 2008
Protein post-translational modifications are of great interest due to their effects on protein structure and function. Our interest lays in the nitration of tyrosine residues by powerful oxidants such as peroxynitrite (ONOO-) forming 3-nitrotyrosine. The
Hong, Sung Jung
core   +1 more source

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Immunochemical Studies on Hen's Egg‐White Lysozyme: Effect of Selective Nitration of the Three Tyrosine Residues

, 1971
By selective nitration of egg‐white lysozyme it is possible to obtain five lysozyme derivatives. Nitration of tyrosine 20 or tyrosine 23 slightly lowers the enzymatic activity and the thermal stability of the protein, modification of tyrosine 53 has a ...
Strosberg, Arthur, Kanarek, Louis, Van Hoeck, Beatrice   +2 more
core   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source