Results 111 to 120 of about 4,897 (216)

A Scaffoldomics Platform for Modular In Vivo Enzyme Colocalisation and Its Application to Naringenin Biosynthesis

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
A hierarchical assembly system was established in which the coding sequences for four docking enzymes and a scaffold are co‐assembled onto a single plasmid, thereby establishing a ‘scaffoldomics’ platform for the optimisation of multi‐enzyme biosynthetic pathways.
Marte Elias, Brecht De Paepe, Julie Vanderstraeten, Babette Lamote, Marjan De Mey, Yves Briers   +5 more
wiley   +1 more source

Genome sequence of the Bacteroides fragilis phage ATCC 51477-B1 [PDF]

, 2008
The genome of a fecal pollution indicator phage, Bacteroides fragilis ATCC 51477-B1, was sequenced and consisted of 44,929 bases with a G+C content of 38.7%.
Shawn A Hawkins, Alice C Layton, Steven Ripp, Dan Williams, Gary S Sayler   +4 more
core   +3 more sources

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Role of phase-variable Mfa1 fimbriae of Phocaeicola vulgatus in its adhesion and proinflammatory activity toward gut epithelial cells

Gut Microbes Reports
Bacteroidaceae is a prominent family in the human gut microbiota. The bacteria within this family are characterized by phase variable regulation of diverse surface structures, such as capsular polysaccharides and outer membrane proteins.
Emmanuel Munyeshyaka, Haruyuki Nakayama-Imaohji, Hisashi Yamasaki, Ayano Tada, Nafisa Tabassum, Tomomi Kuwahara   +5 more
doaj   +1 more source

Characterization of the diverse plasmid pool harbored by the blaNDM-1-containing Acinetobacter bereziniae HPC229 clinical strain.

PLoS ONE, 2019
Acinetobacter bereziniae is an environmental microorganism with increasing clinical incidence, and may thus provide a model for a bacterial species bridging the gap between the environment and the clinical setting. A. bereziniae plasmids have been poorly
Marco Brovedan, Guillermo D Repizo, Patricia Marchiaro, Alejandro M Viale, Adriana Limansky   +4 more
doaj   +1 more source

ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae [PDF]

, 2016
ICEApl1 was identified in the whole genome sequence of MIDG2331, a tetracycline-resistant (MIC = 8 mg/L) serovar 8 clinical isolate of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia. PCR amplification of virB4, one of the
Blanco, Blanco, Bossé, Bossé, Bossé, Boyd, Burrus, Clinical and Laboratory Standards Institute [CLSI], Dimopoulou, Dimopoulou, Eidam, Elhai, European Medicines Agency, Garneau, Guglielmini, Howell, Juhas, Juhas, Juhas, Lin, Michael, Michael, Mohd-Zain, O’Neill, Sentchilo, Sárközi, Wozniak   +26 more
core   +5 more sources

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, Volume 293, Issue 5, Page 1459-1477, March 2026.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata. [PDF]

, 2019
BackgroundThe full scope of the genes expressed by schistosomes during intramolluscan development has yet to be characterized. Understanding the gene products deployed by larval schistosomes in their snail hosts will provide insights into their ...
Bu, Lijing, Buddenborg, Sarah K, Hanelt, Ben, Kamel, Bishoy, Loker, Eric S, Mkoji, Gerald M, Zhang, Si-Ming   +6 more
core   +2 more sources

Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt

Genes to Cells, Volume 31, Issue 2, March 2026.
In the giant Pleurodeles waltl genome, introns serve as “structural buffers,” absorbing transposable elements (TEs) to protect coding exons. While this enables “gene body inflation,” persistent TE accumulation eventually leads to transcriptional silencing and functional collapse, or “burst,” of the gene architecture.
Kazuto Bou, Kiyokazu Agata
wiley   +1 more source

Prepontine non-giant neurons drive flexible escape behavior in zebrafish [PDF]

, 2019
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.
Bergeron, S., Briggman, K., Burgess, H., Marquart, G., Tabor, K.   +4 more
core   +2 more sources