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Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
Neoplasia: An International Journal for Oncology Research, 2006 Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-
Ian R. Watson, Meredith S. Irwin
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Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]
, 2013 SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Azuaga, Ana I. +8 more
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Function of Centriolar Satellites and Regulation by Post-Translational Modifications
Frontiers in Cell and Developmental Biology, 2021 Centriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of ...
Clotilde C. N. Renaud, Nicolas Bidère
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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Nature Communications, 2023 RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and ...
Xiangyi S. Wang +6 more
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To Be or Not to Be...Ubiquitinated? [PDF]
Cell Cycle, 2004 Levels of p21, a cyclin-dependent kinase (CDK) inhibitor, are controlled in part at the post-translational level by protein degradation. Although the signaling pathways leading to p21 degradation have not yet been fully elucidated, it is evident that p21 ubiquitination is an essential factor in its degradation.
Michele Pagano, Joanna Bloom
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The Arabidopsis thaliana E3 Ubiquitin Ligase BRIZ Functions in Abscisic Acid Response
Frontiers in Plant Science, 2021 The ubiquitin system is essential for multiple hormone signaling pathways in plants. Here, we show that the Arabidopsis thaliana E3 ligase BRIZ, a heteromeric ligase that consists minimally of BRIZ1 and BRIZ2 proteins, functions in abscisic acid (ABA ...
Katrina J. Linden +9 more
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Invertebrate Survival Journal, 2021 The increased commercial use of copper oxide nanoparticles (nCuO) led to the release of nanoparticles in wastewaters potentially harming the aquatic biota.
J Auclair +3 more
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Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1
Frontiers in Oncology, 2021 Estrogen receptor α (ERα) is the major driver for breast tumor carcinogenesis and progression, while ERα positive breast cancer is the major subtype in breast malignancies, which account for 70% breast cancers in patients.
Jianing Ding, Peng Kuang, Peng Kuang
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Cracking the Ubiquitin Code: The Ubiquitin Toolbox [PDF]
Current Issues in Molecular Biology, 2019 Ubiquitination, a post-translational modification, regulates a vast array of fundamental biological processes with dysregulation of the dedicated enzymes giving rise to pathologies such as cancer and neurodegenerative diseases. Assembly and its ensuing removal of this post-translational modification, determining a large variety of biological functions,
Mulder, M.P.C., Witting, K.F., Ovaa, H.
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The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
Biomedicines, 2020 Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days.
Susan J. Burke +7 more
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