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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
EMBO Molecular Medicine, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post‐translational modifications controlling virtually all cellular processes.
Simone Fulda +2 more
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Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]
, 2013 SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Azuaga, Ana I. +8 more
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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Nature Communications, 2023 RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and ...
Xiangyi S. Wang +6 more
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Research progress of RNF180 in gastric cancer
生物医学转化, 2022 RNF180 is a type of ring finger protein with ubiquitin ligase activity, which can affect various physiological processes such as cell proliferation, differentiation and apoptosis by participating in the ubiquitinproteasome system. Studies have shown that
Zhang Yating, Wei Yucai, Li Yumin
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SPOP targets the immune transcription factor IRF1 for proteasomal degradation
eLife, 2023 Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon regulatory factor 1 (IRF1)
Irene Schwartz +14 more
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The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
Biomedicines, 2020 Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days.
Susan J. Burke +7 more
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Structural basis for ubiquitylation by HOIL-1
Frontiers in Molecular Biosciences, 2023 The linear ubiquitin chain assembly complex synthesises linear Ub chains which constitute a binding and activation platform for components of the TNF signalling pathway.
Qilong Wu +3 more
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Interplay between septins and ubiquitin-mediated xenophagy during Shigella entrapment
Autophagy Reports, 2023 Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bacteria targeted by ...
Damián Lobato-Márquez +5 more
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Proceedings, 2020 Flaviviruses are enveloped, arthropod-borne, positive-strand RNA viruses that cause significant human disease. While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA ...
Shuo Zhang +8 more
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Deubiquitinating enzymes at the crossroads of lipid metabolism and cancer
Journal of Biological Research - Thessaloniki, 2021 Deregulated lipid metabolism has been recognized as a critical alteration that supports the development and growth of various types of tumors. Changes in lipid metabolism enable reprogramming of energetics and availability of synthetic intermediates and ...
Christos Gonidas +2 more
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