Results 1 to 10 of about 362,377 (322)
An expanded lexicon for the ubiquitin code
Nature reviews. Molecular cell biology, 2022 Recent studies have expanded our understanding of the mechanisms and functions of ubiquitylation. Pathogens rewrite ubiquitylation to promote infection through unconventional ubiquitylation involving lipids and sugars, and structural studies have ...
I. Dikič, B. Schulman
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Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities
Cell Death and Differentiation, 2021 Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline.
Marlene Schmidt +3 more
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E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang +3 more
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International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...].
N. Nakamura
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Nature, 2015 Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
M. Lazarou +8 more
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Emerging functions of branched ubiquitin chains
Cell Discovery, 2021 Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity ...
Michael E. French +2 more
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Mechanical unfolding and refolding pathways of ubiquitin [PDF]
Phys. Rev. Lett. 100, 158104 (2008), 2008 Mechanical unfolding and refolding of ubiquitin are studied by Monte Carlo simulations of a Go model with binary variables. The exponential dependence of the time constants on the force is verified, and folding and unfolding lengths are computed, with good agreement with experimental results. Furthermore, the model exhibits intermediate kinetic states,
arxiv +1 more source
Cellular quality control by the ubiquitin-proteasome system and autophagy
Science, 2019 To achieve homeostasis, cells evolved dynamic and self-regulating quality control processes to adapt to new environmental conditions and to prevent prolonged damage.
C. Pohl, I. Dikič
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NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Nature, 2020 Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein ubiquitylation 1 , which is tightly controlled by the modification of cullin with the ubiquitin-like protein NEDD8 2 – 6 . However, how CRLs catalyse ubiquitylation, and the
Kheewoong Baek +8 more
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Refolding upon force quench and pathways of mechanical and thermal unfolding of ubiquitin [PDF]
Biophysical Journal, 92, 547-561 (2007), 2006 The refolding from stretched initial conformations of ubiquitin (PDB ID: 1ubq) under the quenched force is studied using the Go model and the Langevin dynamics. It is shown that the refolding decouples the collapse and folding kinetics. The force quench refolding times scale as tau_F ~ exp(f_q*x_F/k_B*T), where f_q is the quench force and x_F = 0.96 nm
arxiv +1 more source