Results 1 to 10 of about 289,842 (261)
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Nature Communications, 2023 RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and ...
Xiangyi S. Wang +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
doaj +1 more source
The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
Biomedicines, 2020 Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days.
Susan J. Burke +7 more
doaj +1 more source
Strategies to Investigate Ubiquitination in Huntington's Disease
Frontiers in Chemistry, 2020 Many neurodegenerative disorders including Huntington's Disease are hallmarked by intracellular protein aggregates that are decorated by ubiquitin and different ubiquitin ligases and deubiquitinating enzymes. The protein aggregates observed in Huntington'
Karen A. Sap, Eric A. Reits
doaj +1 more source
SUV39 SET domains mediate crosstalk of heterochromatic histone marks
eLife, 2021 The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin.
Alessandro Stirpe +7 more
doaj +1 more source
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
Frontiers in Cell and Developmental Biology, 2021 Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes.
Immacolata Giordano +15 more
doaj +1 more source
Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma
Frontiers in Cell and Developmental Biology, 2021 Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression ...
Yue Wu +23 more
doaj +1 more source
Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology
Frontiers in Physiology, 2019 F-box proteins, the substrate recognition subunits of SKP1–CUL1–F-box protein (SCF) E3 ubiquitin ligase complexes, play crucial roles in various cellular events mediated by ubiquitination.
Yukiko Yoshida +2 more
doaj +1 more source
Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
doaj +1 more source
Poxvirus Exploitation of the Ubiquitin-Proteasome System
Viruses, 2010 Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been
Alastair Teale +5 more
doaj +1 more source