Results 71 to 80 of about 162,141 (238)

Viral Takeover of the Host Ubiquitin System

Frontiers in Cellular and Infection Microbiology, 2011
Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) protein to substrates has been shown to govern countless cellular ...
Jean K Gustin, Ashlee V Moses, Klaus eFrüh, Janet L Douglas   +3 more
doaj   +1 more source

Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence. [PDF]

, 2007
The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy.
AA, ADAMS, ADAMS, ADAMS, AGHAJANIAN, ALBANELL, AMIRI, AN, ANDERSEN, Antonio Russo, APPLEMAN, ARLT, BANCROFT, BANCROFT, BERENSON, Bruno Vincenzi, CHAUGHAN, CHEN, CHIARLE, CUSACK, CUSACK, Daniele Santini, DAVIES, DAVIES, DAVIS, DEMARCHI, EDELMAN, FAN, FANUCCHI, FINLEY, FRANKEL, Giuseppe Cicero, Giuseppe Tonini, HIDESHIMA, KABORE, KONDAGUNTA, KORSMEYER, KRESGE, KURLAND, LACOMBE, LAURICELLA, LEBLANC, LING, LLOYD, LUDWIG, MA, MAKI, Maria E Fratto, MARX, MELINO, MYUNG, OCEAN, PRICE, RYAN, SAYER, SCHELMAN, SCHMID, SHINORA, STEVENSON, SUN, SUNWOO, SUNWOO, TEICHER, Valentina Agnese, Valentina Schiró, Viviana Bazan, VOORTMAN, WANG, WANG, WILKINSON, WILLIAMS, YANG   +71 more
core   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease

Frontiers in Cell and Developmental Biology
Neurodegenerative diseases are characterized by the progressive breakdown of neuronal structure and function and the pathological accumulation of misfolded protein aggregates and toxic protein oligomers.
Taylor R. Church, Seth S. Margolis, Seth S. Margolis   +2 more
doaj   +1 more source

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Frontiers in Physiology, 2020
Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system functionality.
Saeideh Momtaz, Saeideh Momtaz, Saeideh Momtaz, Zahra Memariani, Fardous F. El-Senduny, Nima Sanadgol, Nima Sanadgol, Fereshteh Golab, Majid Katebi, Amir Hossein Abdolghaffari, Amir Hossein Abdolghaffari, Amir Hossein Abdolghaffari, Amir Hossein Abdolghaffari, Mohammad Hosein Farzaei, Mohammad Hosein Farzaei, Mohammad Abdollahi, Mohammad Abdollahi   +16 more
doaj   +1 more source

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation [PDF]

, 2003
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the ...
Crews, Craig M., Deshaies, Raymond J., Kim, Kyung B., Ransick, Andy, Sakamoto, Kathleen M., Stein, Bernd, Verma, Rati   +6 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS

Сибирский онкологический журнал, 2016
The review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown.
E. V. Ivanova, I. V. Kondakova, О. V. Cheremisina, S. G. Afanasyev   +3 more
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