Results 31 to 40 of about 574,104 (383)

Generation and physiological roles of linear ubiquitin chains [PDF]

, 2012
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
A Ciechanover, A Degterev, A Hershko, A Hershko, A Hershko, A Varshavsky, B Eisenhaber, B Gerlach, C Tokunaga, CK Ea, CM Pickart, CY Ni, DM Wenzel, DW Abbott, EW Doss-Pepe, F Ikeda, F Ikeda, F Ikeda, F Tokunaga, F Tokunaga, F Van Herreweghe, H HogenEsch, H Walczak, H Zhou, Henning Walczak, I Marin, I Marin, Ivan Dikic, J Peng, JN Dynek, JW Harper, Kazuhiro Iwai, KL Lim, M Karin, O Micheau, P Cohen, P de Bie, P Xu, S Hatakeyama, S Rahighi, T Hunter, T Kirisako, TL Haas, V Nagy, VK Chaugule, Y Sato, Y Ye, YC Lo   +47 more
core   +4 more sources

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Nature, 2015
Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
M. Lazarou, Danielle A. Sliter, L. A. Kane, Shireen A. Sarraf, Chunxin Wang, Jonathon L Burman, D. Sideris, A. I. Fogel, R. Youle   +8 more
semanticscholar   +1 more source

Emerging functions of branched ubiquitin chains

Cell Discovery, 2021
Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity ...
Michael E. French, Chad F. Koehler, T. Hunter   +2 more
semanticscholar   +1 more source

Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole [PDF]

, 1992
Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole.
Achstetter, Angela Simeon, Dieter H. Wolf, Doherty, Fujiki, Gropper, Haas, Heinemeyer, Hershko, Hershko, Hershko, Heukeshoven, Ida J. van der Klei, Jones, Kato, Kornfeld, Laemmli, Lowry, Marten Veenhuis, Matile, Mechler, Meyer, Novick, Pennington, Roberts, Schwartz, Siegelman, Spormann, Steck, Teichert, Towbin, Tweto, van, Veenhuis, Wiemken, Yarden   +35 more
core   +3 more sources

In the family with ubiquitin [PDF]

EMBO reports, 2011
The Cold Spring Harbor meeting on ‘The Ubiquitin family’, held in May 2011, brought together scientists from a wide range of fields, all under the common umbrella of ubiquitin and ubiquitin‐like protein structure, function and regulation.
Alexandru, Gabriela, Pariente, Nonia, Xirodimas, Dimitris   +2 more
openaire   +4 more sources

CSF Ubiquitin Levels Are Higher in Alzheimer’s Disease than in Frontotemporal Dementia and Reflect the Molecular Subtype in Prion Disease

Biomolecules, 2020
Disturbances in the ubiquitin-proteasome system seem to play a role in neurodegenerative dementias (NDs). Previous studies documented an increase of cerebrospinal fluid (CSF) free monoubiquitin in Alzheimer’s disease (AD) and Creutzfeldt− ...
Samir Abu-Rumeileh, Patrick Oeckl, Simone Baiardi, Steffen Halbgebauer, Petra Steinacker, Sabina Capellari, Markus Otto, Piero Parchi   +7 more
doaj   +1 more source

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains [PDF]

, 2015
This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin ...
A Plechanovová, A Plechanovová, A Rojas-Fernandez, AA Yunus, AJ McCoy, Anna Plechanovová, AP VanDemark, CE Berndsen, CE Berndsen, CM Guzzo, D Reverter, DC Scott, E Krissinel, Ellis G Jaffray, Emma Branigan, G Winter, GN Murshudov, H Dou, James H Naismith, JN Pruneda, L Chang, L Spyracopoulos, M Scheffner, M Zhang, MB Metzger, MD Winn, MH Tatham, MH Tatham, MJ Eddins, MJ Lewis, P Emsley, P Evans, PY Wu, R Vyas, RM Hofmann, Ronald T Hay, S McKenna, S McKenna, TF Moraes, VB Chen, W Kabsch, Y Galanty, Y Yin   +42 more
core   +3 more sources

Cellular quality control by the ubiquitin-proteasome system and autophagy

Science, 2019
To achieve homeostasis, cells evolved dynamic and self-regulating quality control processes to adapt to new environmental conditions and to prevent prolonged damage.
C. Pohl, I. Dikič
semanticscholar   +1 more source

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection

Frontiers in Microbiology, 2020
The dengue virus presents a serious threat to human health globally and can cause severe, even life-threatening, illness. Dengue virus (DENV) is endemic on all continents except Antarctica, and it is estimated that more than 100 million people are ...
Ashleigh R. Murphy Schafer, Jessica L. Smith, Kara M. Pryke, Victor R. DeFilippis, Alec J. Hirsch   +4 more
doaj   +1 more source

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System [PDF]

, 2011
We have generated a set of dual-reporter human cell lines and devised a chase protocol to quantify proteasomal degradation of a ubiquitin fusion degradation (UFD) substrate, a ubiquitin ligase CRL2^(VHL) substrate, and a ubiquitin-independent substrate ...
Aghajan, Alvarez-Castelao, Bence, Beskow, Boyault, Boyault, Cao, Chou, Colson, Dantuma, DeLaBarre, Deshaies, Ding, Eldridge, Elofsson, Finley, Giaever, Golbik, Ito, Janiesch, Ju, Kane, Kimbrel, Lee, Lois, Milhazes, Müller, Nawrocki, Neuber, Noguchi, Ohh, Patel, Rabouille, Raymond J. Deshaies, Richly, Schrader, Soucy, Tsui-Fen Chou, Tsujimoto, Wang, Wang, Weissman, Yamamoto, Yamamoto, Yamamoto, Yang, Ye, Ye, Ye, Zhang, Zhang   +50 more
core   +3 more sources