Results 41 to 50 of about 574,104 (383)
Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit +4 more
openaire +3 more sources
Cell Reports, 2021 Summary: FBXO31 is the substrate receptor of one of many CUL1-RING ubiquitin ligase (CRL1) complexes. Here, we show that low FBXO31 mRNA levels are associated with high pre-operative prostate-specific antigen (PSA) levels and Gleason grade in human ...
Shanshan Duan +10 more
doaj
The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review
Frontiers in Cellular and Infection Microbiology, 2022 Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S
Prakash Kumar +4 more
doaj +1 more source
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. [PDF]
, 2015 Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes.
Caddick, S +4 more
core +1 more source
Клиническая и экспериментальная тиреоидология, 2016 Actuality. The differential diagnosis of follicular adenoma, follicular variant of papillary thyroid cancer and follicular thyroid cancer (TC) is one of the main topics of research.
Irina S. Berjozkina +10 more
doaj +1 more source
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
eLife, 2020 Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS.
Evan J Worden +2 more
doaj +1 more source
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]
, 2008 Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J. +6 more
core +6 more sources
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Nature, 2020 Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein ubiquitylation 1 , which is tightly controlled by the modification of cullin with the ubiquitin-like protein NEDD8 2 – 6 . However, how CRLs catalyse ubiquitylation, and the
Kheewoong Baek +8 more
semanticscholar +1 more source
Targeting the ubiquitin system by fragment-based drug discovery
Frontiers in Molecular Biosciences, 2022 The ubiquitin system contains a wealth of potential drug targets for many diseases and conditions, including neurodegenerative, immune, metabolic and developmental diseases, as well as multiple cancers.
Cassandra Kennedy +2 more
doaj +1 more source
Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]
, 2019 Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B. +6 more
core +3 more sources