Results 1 to 10 of about 261,936 (280)

The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading.

PLoS ONE, 2021
Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée, Fabienne Podieh, Peter L Hordijk, Igor Kovačević   +3 more
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Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. [PDF]

PLoS ONE, 2013
The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies.
Yuan Zhou, Sixue Liu, Jiangning Song, Ziding Zhang   +3 more
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Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis

Frontiers in Cell and Developmental Biology, 2022
Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based on ...
Xiu Yin, Qingbin Liu, Fen Liu, Xinchen Tian, Xinchen Tian, Tinghao Yan, Tinghao Yan, Jie Han, Shulong Jiang   +8 more
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Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture

Cell & Bioscience, 2022
Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization.
Mingwei Sun, Xiaofei Zhang
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Cellular functions and molecular mechanisms of non-lysine ubiquitination [PDF]

Open Biology, 2019
Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
Amie J. McClellan, Sophie Heiden Laugesen, Lars Ellgaard   +2 more
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Tau Ubiquitination in Alzheimer's Disease

Frontiers in Neurology, 2022
Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation.
Longfei Li, Yanli Jiang, Jian-Zhi Wang, Jian-Zhi Wang, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Xiaochuan Wang, Xiaochuan Wang   +8 more
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Role of K63-linked ubiquitination in cancer

Cell Death Discovery, 2022
Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins.
Liangzi Cao, Xiaofang Liu, Bowen Zheng, Chengzhong Xing, Jingwei Liu   +4 more
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Proteomic Analysis of Ubiquitinated Proteins in Rice (Oryza sativa) After Treatment With Pathogen-Associated Molecular Pattern (PAMP) Elicitors

Frontiers in Plant Science, 2018
Reversible protein ubiquitination plays essential roles in regulating cellular processes. Although many reports have described the functions of ubiquitination in plant defense responses, few have focused on global changes in the ubiquitome.
Xiao-Lin Chen, Xiao-Lin Chen, Xin Xie, Liye Wu, Caiyun Liu, Lirong Zeng, Xueping Zhou, Feng Luo, Guo-Liang Wang, Guo-Liang Wang, Wende Liu   +10 more
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Proteomic Analysis of Protein Ubiquitination Events in Human Primary and Metastatic Colon Adenocarcinoma Tissues

Frontiers in Oncology, 2020
Protein ubiquitination is essential for multiple physiological processes through regulating the stability or function of target proteins and has been found to play critical roles in human cancers.
Yi Zhang, Cong Chen, Tingting Yu, Tao Chen   +3 more
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Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray

Frontiers in Cell and Developmental Biology, 2021
Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU ...
Lijie Zhou, Lijie Zhou, Yingwei Ge, Yesheng Fu, Bo Wu, Yong Zhang, Lei Li, Chun-Ping Cui, Siying Wang, Lingqiang Zhang   +9 more
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