Results 1 to 10 of about 187,561 (340)
Cell & Bioscience, 2022 Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization.
Mingwei Sun, Xiaofei Zhang
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Role of K63-linked ubiquitination in cancer
Cell Death Discovery, 2022 Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins.
Liangzi Cao +4 more
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Cellular functions and molecular mechanisms of non-lysine ubiquitination [PDF]
Open Biology, 2019 Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
Amie J. McClellan +2 more
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EUP: Enhanced cross-species prediction of ubiquitination sites via a conditional variational autoencoder network based on ESM2. [PDF]
PLoS Computational BiologyUbiquitination is critical in biomedical research. Predicting ubiquitination sites based on deep learning model have advanced the study of ubiquitination.
Junhao Liu +6 more
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Comprehensive Ubiquitome Analysis of Nicotiana benthamiana Leaves Infected with Tomato Brown Rugose Fruit Virus [PDF]
BiologyTomato brown rugose fruit virus (ToBRFV) is an important emerging virus that poses a serious threat to the global agricultural economy. Ubiquitination is one of the key post-translational protein modification types in plant responses to biotic stress ...
Jiali Yang +6 more
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Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease [PDF]
HereditasPurpose Ubiquitination is one of the important epigenetic modifications, influencing the development of various diseases. The objective of this study is to investigate the ubiquitination related genes in chronic obstructive pulmonary disease (COPD ...
Shulei Sun, Zhaoxiong Zhang, Haiyan Zhao
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PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
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Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. [PDF]
PLoS ONE, 2013 The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies.
Yuan Zhou +3 more
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Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based on ...
Xiu Yin +8 more
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Tau Ubiquitination in Alzheimer's Disease
Frontiers in Neurology, 2022 Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation.
Longfei Li +8 more
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