Results 181 to 190 of about 308,731 (375)

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology
Transcription factors, pivotal in gene expression regulation, are essential in cancer progression. Their function is meticulously regulated by post‐translational modifications, including ubiquitination. This process, which marks proteins for degradation,
Dongha Kim, Hye Jin Nam, Sung Hee Baek
doaj   +1 more source

An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3

, 2015
Da Xu, Haoxun Wang, Guofeng You
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

RAD6 gene product of Saccharomyces cerevisiae requires a putative ubiquitin protein ligase (E3) for the ubiquitination of certain proteins

, 1991
Gil Sharon, Bilha Raboy, H.A. Parag, Deborah Dimitrovsky, Richard G. Kulka   +4 more
openalex   +1 more source

TBX15/miR-152/KIF2C Pathway Regulates Breast Cancer Doxorubicin Resistance via Preventing PKM2 Ubiquitination [PDF]

, 2020
Chengfei Jiang, Yun-Xia Xie, Ying-Chen Qian, Min Wang, Liu L, Yongqian Shu, Xiaoming Bai, Bing‐Hua Jiang   +7 more
openalex   +1 more source

Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2 [PDF]

, 2023
Yusen Zhang, Liping Liu, Biwei Luo, Honggui Tang, Xiaofang Yu, Shiyun Bao   +5 more
openalex   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Celastrol suppresses mTOR signaling by altering its association with chaperones and inducing its ubiquitination in breast cancer cells

, 2018
Weiying Zhou, Xiaoli Li, Xintong Yao, Duanfang Zhou, Liangyuan Long   +4 more
openalex   +2 more sources

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis

, 2021
Matthew E. R. Maitland, Miljan Kuljanin, Xu Wang, Gilles Lajoie, Caroline Schild‐Poulter   +4 more
openalex   +2 more sources