Results 181 to 190 of about 278,733 (404)
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, EarlyView.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
UNC-104 transport properties are robust and independent of changes in its cargo binding [PDF]
arXivCargo distribution within eukaryotic cells relies on the active transport mechanisms driven by molecular motors. Despite their critical role, the intricate relationship between motor transport properties and cargo binding - and its impact on motor distribution - remains inadequately understood.
arxiv
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation
Frontiers in Microbiology, 2019 High-risk Human papillomaviruses (HPVs) types are associated with more than 90% of premalignant and malignant squamous lesions of the uterine cervix. The E6 oncoprotein of high-risk HPVs is a key determinant in cell transformation because it induces the ...
Siying Li +9 more
semanticscholar +1 more source
A transient increase in histone H2A ubiquitination is coincident with the onset of erythroleukemic cell differentiation [PDF]
, 1988 JO Hensold, PS Swerdlow, DE Housman
openalex +1 more source
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
Visualizing ubiquitination in mammalian cells
EMBO Reports, 2019 Covalent modification of proteins with ubiquitin is essential for the majority of biological processes in mammalian cells. Numerous proteins are conjugated with single or multiple ubiquitin molecules or chains in a dynamic fashion, often determining ...
Sjoerd J. L. van Wijk +3 more
semanticscholar +1 more source
Auto-ubiquitination of ubiquitin-activating enzymes from chicken breast muscle [PDF]
, 1990 J.E. Arnold, Wieland Gevers
openalex +1 more source
piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization
Advanced Science, EarlyView.PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang +16 more
wiley +1 more source
SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation [PDF]
arXiv, 2004 Small Ubiquitin-related modifier (SUMO) proteins are widely expressed in eukaryotic cells, which are reversibly coupled to their substrates by motif recognition, called sumoylation. Two interesting questions are 1) how many potential SUMO substrates may be included in mammalian proteomes, such as human and mouse, 2) and given a SUMO substrate, can we ...
arxiv
Advanced Science, EarlyView.In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han +10 more
wiley +1 more source