Results 21 to 30 of about 187,561 (340)
The role of Ubiquitination in Apoptosis and Necroptosis
Cell Death and Differentiation, 2021 Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially harmful cells from within an organism, such as cells with damaged DNA that could lead to cancer.
Jamie Z. Roberts +2 more
semanticscholar +1 more source
The role of ubiquitination in tumorigenesis and targeted drug discovery
Signal Transduction and Targeted Therapy, 2020 Ubiquitination, an important type of protein posttranslational modification (PTM), plays a crucial role in controlling substrate degradation and subsequently mediates the “quantity” and “quality” of various proteins, serving to ensure cell homeostasis ...
Lu Deng +4 more
semanticscholar +1 more source
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response
Cellular & Molecular Immunology, 2021 Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a at Lys119.
Zengguo Cao +5 more
semanticscholar +1 more source
Cell Research, 2016 Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code ...
Kirby N Swatek, David Komander
openaire +2 more sources
The role of ubiquitination and deubiquitination in cancer metabolism
Molecular Cancer, 2020 Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth.
Tianshui Sun, Zhuonan Liu, Qing Yang
semanticscholar +1 more source
Frontiers in Plant Science, 2018 Reversible protein ubiquitination plays essential roles in regulating cellular processes. Although many reports have described the functions of ubiquitination in plant defense responses, few have focused on global changes in the ubiquitome.
Xiao-Lin Chen +10 more
doaj +1 more source
Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
Frontiers in Cell and Developmental Biology, 2021 Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU ...
Lijie Zhou +9 more
doaj +1 more source
Regulation of ubiquitin and ubiquitin‐like modifiers by phosphorylation [PDF]
The FEBS Journal, 2021 The regulatory influence of ubiquitin is vast, encompassing all cellular processes, by virtue of its central roles in protein degradation, membrane trafficking, and cell signaling. But how does ubiquitin, a 76 amino acid peptide, carry out such diverse, complex functions in eukaryotic cells? Part of the answer is rooted in the high degree of complexity
Nathaniel L. Hepowit +4 more
openaire +3 more sources
Frontiers in Plant Science, 2022 Lysine ubiquitination is a highly conserved post-translational modification with diverse biological functions. However, there is little available information on lysine ubiquitination of non-histone proteins in papaya (Carica papaya L.).
Yuxing Mo +9 more
doaj +1 more source
Nature Communications, 2020 Production of reactive oxygen species (ROS) is critical for successful activation of immune responses against pathogen infection. The plant NADPH oxidase RBOHD is a primary player in ROS production during innate immunity. However, how RBOHD is negatively
Donghyuk Lee +8 more
semanticscholar +1 more source