Results 21 to 30 of about 278,733 (404)
Beyond K48 and K63: non-canonical protein ubiquitination
Cellular & Molecular Biology Letters, 2021 Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly regulated proteolysis, ubiquitination is now regarded as essential for many other cellular ...
M. Tracz, W. Białek
semanticscholar +1 more source
Tau Ubiquitination in Alzheimer's Disease
Frontiers in Neurology, 2022 Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation.
Longfei Li +8 more
doaj +1 more source
Role of K63-linked ubiquitination in cancer
Cell Death Discovery, 2022 Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins.
Liangzi Cao +4 more
doaj +1 more source
Ubiquitination is essential for recovery of cellular activities after heat shock
Science, 2021 Tailoring stress responses When faced with environmental stress, cells respond by shutting down cellular processes such as translation and nucleocytoplasmic transport.
Brian A. Maxwell +7 more
semanticscholar +1 more source
The role of Ubiquitination in Apoptosis and Necroptosis
Cell Death and Differentiation, 2021 Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially harmful cells from within an organism, such as cells with damaged DNA that could lead to cancer.
Jamie Z. Roberts +2 more
semanticscholar +1 more source
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease. [PDF]
HereditasPurpose Ubiquitination is one of the important epigenetic modifications, influencing the development of various diseases. The objective of this study is to investigate the ubiquitination related genes in chronic obstructive pulmonary disease (COPD ...
Sun S, Zhang Z, Zhao H.
europepmc +2 more sources
The role of ubiquitination in tumorigenesis and targeted drug discovery
Signal Transduction and Targeted Therapy, 2020 Ubiquitination, an important type of protein posttranslational modification (PTM), plays a crucial role in controlling substrate degradation and subsequently mediates the “quantity” and “quality” of various proteins, serving to ensure cell homeostasis ...
Lu Deng +4 more
semanticscholar +1 more source
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response
Cellular & Molecular Immunology, 2021 Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a at Lys119.
Zengguo Cao +5 more
semanticscholar +1 more source
The role of ubiquitination and deubiquitination in cancer metabolism
Molecular Cancer, 2020 Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth.
Tianshui Sun, Zhuonan Liu, Qing Yang
semanticscholar +1 more source
Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
Frontiers in Cell and Developmental Biology, 2021 Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU ...
Lijie Zhou +9 more
doaj +1 more source