Results 81 to 90 of about 851 (145)
ACS Omega, 2022 Ubiquitination is a major posttranslational modification of proteins that affects their stability, and E3 ligases play a key role in ubiquitination by specifically recognizing their substrates. BTBD9, an adaptor of the Cullin-RING ligase complex, is responsible for substrate recognition and is associated with sleep homeostasis.
Zhenfei Gao +12 more
openaire +2 more sources
Utilizing and expanding the mass spectrometry toolbox:Exploring the ubiquitinome of proteasomally-modulated cells [PDF]
Human bodies are made up of billions of cells, which in turn are very small living entities which can be compared to small factories. These factories use very small machines, in the form of proteins, to stay alive and perform the various functions ...
van der Wal, Lennart
core +5 more sources
Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking [PDF]
, 2016 A fascinating conundrum in cell signaling is how stimulation of the same receptor tyrosine kinase with distinct ligands generates specific outcomes. To decipher the functional selectivity of EGF and TGF-α, which induce epidermal growth factor receptor ...
Blagoev, Blagoy +8 more
core +1 more source
Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.Abstract Background Myocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐specific protease (USP) family of DUBs, are key proteins in the ubiquitination modification process and play
Bozhi Ye +10 more
wiley +1 more source
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry [PDF]
, 2023 Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the presynaptic plasma membrane, leading ...
Ainatzi, Sofia
core +1 more source
Biotechnology Journal, Volume 19, Issue 11, November 2024.Graphical Abstract and Lay Summary Ubiquitination is an essential cellular process in which proteins are tagged with ubiquitin, marking them for proteasomal degradation. Beyond this role, ubiquitination plays key functions in ER stress, cell signalling, autophagy, and cell cycle regulation. To gain deep insights into ER stress mechanisms and changes to
Karuppuchamy Selvaprakash +5 more
wiley +1 more source
Quantitative proteomics reveals extensive lysine ubiquitination in the Arabidopsis root proteome and uncovers novel transcription factor stability states [PDF]
, 2021 Protein activity, abundance, and stability can be regulated by posttranslational modification including ubiquitination. Ubiquitination is conserved among eukaryotes and plays a central role in modulating cellular function and yet we lack comprehensive ...
Clark, Natalie +7 more
core +2 more sources
Ubiquitin signalling in Drosophila innate immune responses
The FEBS Journal, Volume 291, Issue 20, Page 4397-4413, October 2024.Drosophila innate immunity against bacterial infection relies on humoral responses regulated by the Imd and Toll pathways activating NF‐κB transcription factors, as well as JNK activation and JAK/STAT signalling. These pathways are characterised by E3 ligases and deubiquitinating enzymes that determine ubiquitination of signalling molecules followed by
Anna L. Aalto +2 more
wiley +1 more source
Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence. [PDF]
, 2019 Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat ...
Burke, Thomas P +9 more
core
Genetic variation in ZmKW1 contributes to kernel weight and size in dent corn and popcorn
Plant Biotechnology Journal, Volume 22, Issue 6, Page 1453-1467, June 2024.Summary Kernel weight is a critical factor that essentially affects maize (Zea mays) yield. In natural inbred lines, popcorn kernels exhibit overtly smaller sizes compared to dent corn kernels, and kernel weight, which is controlled by multiple genetic loci, varies widely.
Long Zhang +13 more
wiley +1 more source