Results 241 to 250 of about 97,644 (305)

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Structural and Functional Analyses of <i>Trypanosoma brucei</i> Nucleoside Diphosphate Kinase. [PDF]

ACS Omega
Makori P, Boeckman MP, David HS, Payne F, Gatling M, Greer C, Hayes D, Jefferson A, Maxwell M, Smith C, Watson J, Williams L, Barkley J, Pepper C, Zininga T, Subramanian S, Abramov A, Gardberg AS, Edwards TE, Staker BL, Stewart LJ, Myler PJ, Asojo OA, Jeje O, Fanucchi S, Achilonu I, Smith CL, Chakafana G.   +27 more
europepmc   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

P2Y2 Purinergic Receptor Promotes Trafficking of Hematopoietic Stem/Progenitor Cells (HSPCs). [PDF]

Stem Cell Rev Rep
Adamiak M, Brzezniakiewicz-Janus K, Molenda M, Ratajczak J, Tang Y, Kucia M, Ratajczak MZ.   +6 more
europepmc   +1 more source

Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual‐Purpose Defense Metabolite in Sorghum bicolor

Plant Direct, Volume 10, Issue 8, August 2026.
ABSTRACT Dhurrin, a cyanogenic glucoside, plays an important role in Sorghum bicolor physiology and defense. The concentration of dhurrin in sorghum is influenced by both nitrogen status and stage of plant organ development. While nitrogen resupply activates the expression of genes for dhurrin biosynthesis, the molecular mechanisms underlying this ...
Alicia A. Quinn, Brian A. McKinley, Cecilia K. Blomstedt, John E. Mullet, Roslyn M. Gleadow   +4 more
wiley   +1 more source

Phylogenetic analysis reveals diversity in glycan biosynthesis in "<i>Candidatus</i> Accumulibacter". [PDF]

Biofilm
Eerden SA, Abeel T, van Loosdrecht MCM, Roy S.   +3 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. [PDF]

Nat Chem Biol
Li Z, Chawla H, Di Vagno L, Ní Cheallaigh A, Critcher M, Sammon D, Gonzalez-Rodriguez E, Briggs DC, Chung N, Chang V, Mahoney KE, Cioce A, Bineva-Todd G, Wang PY, Liu YC, Murphy LD, Chen YH, Narimatsu Y, Miller RL, Willems LI, Malaker SA, Huang ML, Miller GJ, Hohenester E, Schumann B.   +24 more
europepmc   +1 more source

Security Assessment of Private Package Repositories: An Experience on Acc‐Py at CERN

Journal of Software: Evolution and Process, Volume 38, Issue 8, August 2026.
ABSTRACT The introduction of package managers had a huge impact on software development, as they facilitate dependency management and the access to reusable code components. However, reliance on centralized repositories introduces security risks, as they are increasingly exploited in supply chain attacks.
Michele Lizzit, Francesco Pinzauti, Marino Miculan, Vincenzo Riccio   +3 more
wiley   +1 more source

P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology. [PDF]

Purinergic Signal
da Silva Ebone R, Doleski PH, Jantsch MH, da Silveira RP, Leal DBR.   +4 more
europepmc   +1 more source