Results 181 to 190 of about 9,904 (211)
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Structure of UDPâGlucuronosyltransferases in Membranes
2005This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endoplasmic reticulum (ER).
Sylvie Fournel-Gigleux +3 more
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Cloning and Characterization of a Canine UDP-Glucuronosyltransferase
Archives of Biochemistry and Biophysics, 2001UDP-glucuronosyltransferases (UGTs) are a major family of enzymes catalyzing the transfer of glucuronic acid to a range of endogenous compounds and xenobiotics facilitating their elimination in either urine or bile. Although the dog is commonly used in drug metabolism studies, relatively little is known about the expression and activity of UGTs in this
D.J. Smith +3 more
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UDP-glucuronosyltransferases: a family of detoxifying enzymes
Trends in Pharmacological Sciences, 1990Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism.
Brian Burchell, Thomas R. Tephly
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Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism
Current Drug Metabolism, 2005UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro Maruo +4 more
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Isolation and purification of UDP-glucuronosyltransferases
Chemical Research in Toxicology, 1990UDPGTs are members of a class of enzymes located in the endoplasmic reticulum and are encoded by a multigene family. These proteins are responsible for the glucuronidation of hundreds of xenobiotics of many chemical classes and many endogenous substances such as steroid hormones, bile acids, and bilirubin.
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Development of Human Liver UDP-Glucuronosyltransferases
Developmental Pharmacology and Therapeutics, 1989The development of multiple UDPGT activities towards eight substrates has been studied in fetal term and adult post-mortem (less than 5 h after death) liver samples. Most fetal and term liver activities were less than 14% of adult values, except that towards 5-hydroxytryptamine which was present in fetal and term liver at adult levels.
David Harding +6 more
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Natural and synthetic inhibitors of UDP-glucuronosyltransferase
Pharmacology & Therapeutics, 2001Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides.
Zlatina Naydenova +3 more
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The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A
Xenobiotica, 20161. The exposed level of vitamin A in plasma might be exceeded due to the both inadvertent and clinical utilization. The adverse effects of vitamin A have been frequently reported, however, the mechanism remains unclear. The inhibition of vitamin A on the activity of UDP-glucuronosyltransferases (UGTs) was determined using in vitro incubation system to ...
Liang-Liang Zhu +9 more
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Polymorphisms of UDP-Glucuronosyltransferase and Pharmacokinetics of Irinotecan
Therapeutic Drug Monitoring, 2002Irinotecan is a prodrug that is hydrolyzed by carboxylesterase in vivo to form an active metabolite SN-38. SN-38 is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) to yield its beta-glucuronide (SN-38G). Although irinotecan is widely used, the drug causes unpredictably severe, occasionally fatal, toxicity of leukopenia or ...
Hiroshi Ueoka +5 more
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A Major Genotype in UDP-glucuronosyltransferase 2B15
Drug Metabolism and Pharmacokinetics, 2002A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'.
Toshihiko Fujii +6 more
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