Results 191 to 200 of about 9,904 (211)
Some of the next articles are maybe not open access.
Transcriptional Regulation of UDP-Glucuronosyltransferases
2009Totowa, New ...
Xie, Wen +2 more
openaire +1 more source
STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
Drug Metabolism Reviews, 1999UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GIcUA) as the sugar donor. Glucuronidation is a major factor in the elimination of lipophilic compounds from the body. In
Anna Radominska-Pandya +4 more
openaire +3 more sources
Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Geoff Hammond +4 more
openaire +3 more sources
Inhibition of UDP-glucuronosyltransferases (UGTs) by bromophenols (BPs)
Chemosphere, 2020Bromophenols (BPs) are important organic compounds which have become dominant pollutants during these years. Our present study investigated the potential inhibition behaviour of BPs on the activity of one of the most important phase II drug-metabolizing enzymes (DMEs), UDP-glucuronosyltransferases (UGTs). Recombinant UDP-glucuronosyltransferases (UGTs)-
Kai Yang +6 more
openaire +3 more sources
Metabolism of Endobiotics and Xenobiotics by UDP-Glucuronosyltransferase
1997Publisher Summary All organisms are exposed to a number of chemical compounds that are toxic were it not for metabolic mechanisms available to the organism to moderate their effects. Chemical substances may be xenobiotics, such as drugs, or compounds presented to the organism from environmental or dietary sources.
Mitchell D. Green +5 more
openaire +3 more sources
Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance
Toxicology, 2002UDP-Glucuronosyltransferase (UGT), the microsomal enzyme responsible for glucuronidation reactions, exists as a superfamily of enzymes. Genetic polymorphism has been described for 6 of the 16 functional human UGT genes characterised to date, namely UGT 1A1, 1A6, 1A7, 2B4, 2B7 and 2B15.
Ross A. McKinnon +2 more
openaire +3 more sources
The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification
The International Journal of Biochemistry & Cell Biology, 2013Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of the UGT1A and 2B subfamilies play a key role in terminating the biological actions and enhancing the renal elimination of non-polar (lipophilic) drugs from all therapeutic ...
Rowland, Andrew +2 more
openaire +4 more sources
Transcriptional regulation of human UDP-glucuronosyltransferase genes
Drug Metabolism Reviews, 2014Glucuronidation is an important metabolic pathway for many small endogenous and exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids, carcinogens and therapeutic drugs. Glucuronidation is primarily catalyzed by the UDP-glucuronosyltransferase (UGT) 1A and two subfamilies, including nine functional UGT1A enzymes (1A1, 1A3 ...
Dong Gui Hu +3 more
openaire +3 more sources
Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi
Critical Reviews in Biochemistry and Molecular Biology, 1991UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. In this way they prevent their further oxidation to electrophiles, which may react with DNA, RNA, and protein.
openaire +2 more sources
Regulation of the human bilirubin UDP-glucuronosyltransferase gene
Advances in Enzyme Regulation, 1996The human UGT1 gene is a single copy gene consisting of four common exons and more than 13 variable exons which span more than 200 kb of the human genome. A single variable exon is spliced to the four common exons to form the mRNA for synthesis of a single UDP-glucuronosyltransferase (UGT) isoenzyme.
Mei Hui Hsu +5 more
openaire +3 more sources