Results 51 to 60 of about 9,904 (211)

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases

Frontiers in Physiology, 2018
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the
Yiou Pan, Fayi Tian, Xiang Wei, Yongqiang Wu, Xiwu Gao, Jinghui Xi, Qingli Shang   +6 more
doaj   +1 more source

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri, Asaph Aharoni   +6 more
wiley   +1 more source

Dosage Adjustment of Irinotecan in Patients with UGT1A1 Polymorphisms: A Review of Current Literature

INNOVATIONS in Pharmacy, 2020
Objective: To review available literature regarding pharmacogenomics (PGx) effects on the metabolism of irinotecan by the UGT1A1 gene and the resulting dose adjustments based on PGx genetic variant. Summary: Irinotecan is a chemotherapy agent commonly
Lia Argevani, Caren Hughes, Michael J. Schuh   +2 more
doaj   +1 more source

Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa

Plant Biotechnology Journal, EarlyView.
Summary Saponins constitute a class of characteristic compounds within quinoa grains. In this study, metabolomic analysis identified 20 triterpene saponins, the majority of which were exclusively localized within the pericarp. Furthermore, three crucial glycosyltransferases were identified in quinoa.
Yiming Zhang, Peng Zhu, Long Wu, Zhaohui Li, Yongshun Huang, Mingyu Wang, Kaiying Gu, Peng Wang, Jun Li, Huihua Wan, Hailong Zhang, Jianghua Chen, Ruikun He, Wei Sun, Lixin Li   +14 more
wiley   +1 more source

Flunitrazepam increases the risk of lamotrigine‐induced cutaneous adverse reactions: Combined analysis of medical big data and clinical research

Psychiatry and Clinical Neurosciences, EarlyView.
Aim The concomitant use of lamotrigine and valproic acid, a uridine diphosphate (UDP)‐glucuronosyltransferase inhibitor, is a known risk factor for lamotrigine‐induced rashes, which may develop into fatal or severe cutaneous adverse reactions. No drugs other than valproic acid have been shown to increase lamotrigine concentrations in humans by ...
Hiroshi Bando, Mitsuhiro Goda, Masahito Nakataki, Keita Hirai, Yuki Nitta, Kei Kawada, Toshihiko Yoshioka, Masaya Kanda, Atsushi Ogawa, Chiaki Mukuta‐Murakami, Kaito Tsujinaka, Koji Miyata, Kohei Kitagawa, Takahiro Niimura, Fuka Aizawa, Kenta Yagi, Yuki Izawa‐Ishizawa, Masayuki Chuma, Takafumi Naito, Yoshikazu Tasaki, Shusuke Numata, Keisuke Ishizawa   +21 more
wiley   +1 more source

Rhizobacteria prime the activation of plant defense and nutritional responses to suppress aphid populations on barley over time

New Phytologist, Volume 247, Issue 5, Page 2390-2405, September 2025.
Summary Interactions between plants and soil microbes are widespread and are documented to modulate plant–insect herbivore interactions. Still, it remains unclear how these shape the overall plant defense responses and the mechanisms in suppressing insect populations.
Crispus M. Mbaluto, Sharon E. Zytynska
wiley   +1 more source

UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia

Acta Medica Iranica, 2013
To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic ...
Mahbod Kaveh, Tahereh Esmailnia, Fatemeh Nayeri, Firoozeh Nili, Fatemeh Davari Tanha, Mahsa Ghajarzdeh   +5 more
doaj  

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 497-509, August 2025.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Serum bilirubin affects graft outcomes through UDP-glucuronosyltransferase sequence variation in kidney transplantation.

PLoS ONE, 2014
BackgroundOxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.
Jung Pyo Lee, Do Hyoung Kim, Seung Hee Yang, Jin Ho Hwang, Jung Nam An, Sang Il Min, Jongwon Ha, Yun Kyu Oh, Yon Su Kim, Chun Soo Lim   +9 more
doaj   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 438-448, August 2025.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source