Results 51 to 60 of about 7,973 (164)

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7

Frontiers in Pharmacology, 2022
Human UDP-glucuronosyltransferase (UGT) 2B7 is a crucial phase II metabolic enzyme that transfers glucuronic acid from UDP-glucuronic acid (UDPGA) to endobiotic and xenobiotic substrates.
Jia Xue, Haitao Zhang, Haitao Zhang, Su Zeng   +3 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1095-1104, April 2026.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo, Donna A. Volpe, Anik Chaturbedi, Aanchal Shah, Ashok Krishna, Paula L Hyland, Giri Vegesna, Cheng‐Hui Hsiao, Ryan De Palma, Melanie Fein, Rodney Rouse, Jeffry Florian   +11 more
wiley   +1 more source

Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes

Pharmaceutics, 2019
Catalposide, an active component of Veronica species such as Catalpa ovata and Pseudolysimachion lingifolium, exhibits anti-inflammatory, antinociceptic, anti-oxidant, hepatoprotective, and cytostatic activities.
Deok-Kyu Hwang, Ju-Hyun Kim, Yongho Shin, Won-Gu Choi, Sunjoo Kim, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee   +8 more
doaj   +1 more source

Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)

Animals, 2022
UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, Mayumi Ishizuka   +4 more
doaj   +1 more source

Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index [PDF]

, 2011
In PressIn humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive ...
Bronze-da-Rocha, Elsa, Carvalho, João, Costa, Elísio, Rocha-Pereira, Petronila, Rodrigues, Carina, Santos, Rosário, Santos-Silva, Alice, Vieira, Emília   +7 more
core   +1 more source

Population Pharmacokinetic Model Assessment of the Effects of Body Weight on Risk of Drug–Drug Interactions After Posaconazole Discontinuation

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Posaconazole is a broad‐spectrum triazole antifungal agent indicated for the prophylaxis and treatment of invasive fungal infections. Posaconazole pharmacokinetics and drug–drug interactions (DDIs), due to cytochrome P450 3A4 (CYP3A4) inhibition, have been previously characterized.
Rebecca E. Wrishko, Thomas J. Bateman, Matthew G. Johnson, Prajakti A. Kothare   +3 more
wiley   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, Volume 24, Issue 4, Page 1936-1949, April 2026.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Case Reports in Medicine, 2011
Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas, Olga Liapi, Anna Papadopoulou, Polyxeni Nicolaidou, Alexandra Stamoulakatou   +4 more
doaj   +1 more source

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]

The Pharmacogenomics Journal, 2003
UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
openaire   +2 more sources