Results 61 to 70 of about 9,904 (211)

Recent Perspectives on the Role of Anthocyanins in Blueberries (Vaccinium spp.) Against Cardiovascular Diseases and Their Complications: An Updated Review

eFood, Volume 6, Issue 4, August 2025.
Given the global burden of CVDs as a leading cause of mortality, our review aims to address the urgent need for improved dietary interventions. Key findings highlight that blueberry anthocyanins enhance endothelial function, modulate inflammatory pathways, and mitigate oxidative stress.
Muhammad Tayyab Arshad, Sammra Maqsood, Ali Ikram, Muhammed Adem Abdullahi   +3 more
wiley   +1 more source

Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Ictalurus punctatus)

Animals
Sulfamethoxazole is a widely used antimicrobial drug used to treat bacterial diseases in aquaculture. To understand the gene expression in channel catfish liver after treatment with sulfamethoxazole, in this study, the treatment group received ...
Xiangxuan Du, Ruyu Sun, Lei Zhang, Yongtao Liu, Xiaohui Ai   +4 more
doaj   +1 more source

The Beneficial Effects of Berberine on Brain Functions in Age‐Related Neurological Disorders: From Molecular Signaling to Treatment

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The positive influence of berberine on the nervous system can be attributed to its diverse effects on multiple targets. The effects of berberine include its antioxidant, anti‐apoptotic, anti‐necroptotic, and anti‐inflammatory properties, as well as its ability to induce autophagy.
Xiaolan Wang, Ruiliang Hou, Zhihao Chen, Xiaoyang Wang, Melika Malek, Haoyu Wang   +5 more
wiley   +1 more source

Induction of UDP-glucuronosyltransferase 1A by naturally occurring phytochemicals in human hepatoma cells

Journal of Medical Science, 2014
UDP-glucuronosyltransferases (UGTs) are important detoxification and drug-metabolizing enzymes, which catalyse the glucuronidation of exogenous and endogenous chemicals. The anti-carcinogenic activity of dietary phytochemicals is partly attributed to the
Violetta Krajka-Kuźniak, Adam Krysztofiak, Jarosław Paluszczak   +2 more
doaj   +1 more source

Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
Curcumin regulates several signaling pathways linked to neuroprotection, such as those that reduce oxidative stress, prevent Aβ formation, and decrease neuroinflammation. ABSTRACT Progressive neuronal loss and dysfunction characterize neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and Huntington's diseases, spinal cord injury, and ...
Md. Rezaul Islam, Abdur Rauf, Sumiya Akter, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Md. Tazul Islam, Hassan A. Hemeg, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Marcello Iriti   +11 more
wiley   +1 more source

Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf, Jessica Berdougo‐Tritz, Lucie Augey, Aïcha Mbarek, Michel Jadoul, Gilbert Deray, Ziad A. Massy   +6 more
wiley   +1 more source

Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs

Lipids in Health and Disease, 2012
Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane, Gessner Denise K, Most Erika, Eder Klaus, Ringseis Robert   +4 more
doaj   +1 more source

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape‐enhancing saponins

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3068-3082, August 2025.
Summary The limited cytosolic delivery of DNA and protein‐based therapeutics due to endosomal entrapment reduces drug efficacy, increasing treatment costs and possible side effects in human and veterinary medicine as a consequence of higher administered dosages.
Elia Lacchini, Tongtong Qu, Tessa Moses, Alexander N. Volkov, Alain Goossens   +4 more
wiley   +1 more source

A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source

Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero [PDF]

, 1977
G. J. Wishart, Geoffrey J. Dutton
openalex   +1 more source