Results 11 to 20 of about 60,978 (228)

UDP-glycosyltransferase UGT96C10 functions as a novel detoxification factor for conjugating the activated dinitrotoluene sulfonate in switchgrass. [PDF]

Plant Biotechnol J
Summary Dinitrotoluene sulfonates (DNTSes) are highly toxic hazards regulated by the Resource Conservation and Recovery Act (RCRA) in the United States.
Su K, Wu Z, Liu Y, Wang Y, Wang H, Liu M, Wang Y, Wang H, Fu C.   +8 more
europepmc   +2 more sources

Role of UDP-Glycosyltransferase (ugt) Genes in Detoxification and Glycosylation of 1-Hydroxyphenazine (1-HP) in Caenorhabditis elegans. [PDF]

Chem Res Toxicol
Caenorhabditis elegans is a useful model organism to study the xenobiotic detoxification pathways of various natural and synthetic toxins, but the mechanisms of phase II detoxification are understudied.
Asif MZ, Nocilla KA, Ngo L, Shah M, Smadi Y, Hafeez Z, Parnes M, Manson A, Glushka JN, Leach FE, Edison AS.   +10 more
europepmc   +2 more sources

Computational-guided discovery of UDP-glycosyltransferases for lauryl glucoside production using engineered E. coli [PDF]

Bioresources and Bioprocessing
Defining suitable enzymes for reaction steps in novel synthetic pathways is crucial for developing microbial cell factories for non-natural products. Here, we developed a computational workflow to identify C12 alcohol-active UDP-glycosyltransferases. The
Kasimaporn Promubon, Kritsada Tathiya, Aussara Panya, Wasu Pathom-Aree, Pachara Sattayawat   +4 more
doaj   +2 more sources

The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes. [PDF]

Cancers (Basel), 2021
Simple Summary The human UDP-glycosyltransferase (UGT) superfamily plays a critical role in the metabolism of numerous endogenous and exogenous small lipophilic compounds, including carcinogens, drugs, and bioactive molecules with pro- or anti-cancer ...
Hu DG, Marri S, Mackenzie PI, Hulin JA, McKinnon RA, Meech R.   +5 more
europepmc   +2 more sources

UDP-Glycosyltransferases in Edible Fungi: Function, Structure, and Catalytic Mechanism [PDF]

Fermentation, 2023
UDP-glycosyltransferases (UGTs) are the most studied glycosyltransferases, and belong to large GT1 family performing the key roles in antibiotic synthesis, the development of bacterial glycosyltransferase inhibitors, and in animal inflammation.
Yumeng Yang, Yingying Liang, Fengjie Cui, Yongli Wang, Lei Sun, Xinyi Zan, Wenjing Sun   +6 more
doaj   +2 more sources

Discovering New Substrates of a UDP-Glycosyltransferase with a High-Throughput Method. [PDF]

Int J Mol Sci
UDP-glycosyltransferases (UGTs) form a large enzyme family that is found in a wide range of organisms. These enzymes are known for accepting a wide variety of substrates, and they derivatize xenobiotics and metabolites for detoxification.
Lethe MCL, Bui D, Hu M, Wang X, Singh R, Chan CTY.   +5 more
europepmc   +2 more sources

The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. [PDF]

Front Physiol, 2021
UDP-glycosyltransferases (UGTs) are important conjugation enzymes found in all kingdoms of life, catalyzing a sugar conjugation with small lipophilic compounds and playing a crucial role in detoxification and homeostasis.
Ahn SJ, Marygold SJ.
europepmc   +2 more sources

Genome-wide investigation of UDP-Glycosyltransferase family in Tartary buckwheat (Fagopyrum tataricum). [PDF]

BMC Plant Biol
Tartary buckwheat (Fagopyrum tataricum) belongs to Polygonaceae family and has attracted increasing attention owing to its high nutritional value. UDP-glycosyltransferases (UGTs) glycosylate a variety of plant secondary metabolites to control many ...
Yang F, Zhang L, Zhang X, Guan J, Wang B, Wu X, Song M, Wei A, Liu Z, Huo D.   +9 more
europepmc   +2 more sources

Genome-Wide Analysis of the UDP-Glycosyltransferase Family Reveals Its Roles in Coumarin Biosynthesis and Abiotic Stress in Melilotus albus. [PDF]

Int J Mol Sci, 2021
Coumarins, natural products abundant in Melilotus albus, confer features in response to abiotic stresses, and are mainly present as glycoconjugates. UGTs (UDP-glycosyltransferases) are responsible for glycosylation modification of coumarins.
Duan Z, Yan Q, Wu F, Wang Y, Wang S, Zong X, Zhou P, Zhang J.   +7 more
europepmc   +2 more sources

Editorial: Invertebrate UDP-Glycosyltransferases: Nomenclature, Diversity and Functions [PDF]

Frontiers in Physiology, 2021
International ...
Seung-Joon Ahn, Thomas Chertemps, Martine Maïbèche, Steven J. Marygold, Thomas Van Leeuwen   +4 more
doaj   +6 more sources