Results 121 to 130 of about 211,543 (281)
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley +1 more source
[UDP-glucuronosyltransferase].
UDP-glucuronosyltransferases (UGTs) represent a family of enzymes that glucuronidate many internal substances and drugs. This family acts as a drug metabolism phase II reactor in the liver and comprises one of the major protective mechanisms from toxic chemical substances. UGTs have two subfamilies; UGT1 and UGT2.
Yoshihiro, Maruo, Hiroshi, Sato
openaire +1 more source
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn +6 more
wiley +1 more source
The Performance of a Second Generation Service Discovery Protocol In Response to Message Loss [PDF]
We analyze the behavior of FRODO, a second generation service discovery protocol, in response to message loss in the network. Earlier protocols, like UPnP and Jini rely on underlying network layers to enhance their failure recovery.
Glind, G.J. van de +3 more
core +3 more sources
Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa +4 more
wiley +1 more source
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola +11 more
wiley +1 more source
Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang +3 more
wiley +1 more source
High‐quality genomes of four wild raspberry species, analysis of their genetic relationships, identification of centromeres as markers for tracing their hybrid origins, exploration of fruit quality regulation, and discovery of a gene blocking anthocyanin transport and thus causing yellow fruits provides valuable resources for raspberry breeding ...
Ticao Zhang +11 more
wiley +1 more source

