Results 171 to 180 of about 81,476 (261)

Spatial metabolomic mapping reveals peel-color- and tissue-region-associated metabolic heterogeneity in postharvest 'Yanzhihong' apricot fruit. [PDF]

Front Plant Sci
Shi X, Zhao Y, Jia W, Zhang H, Cui A, He Y.   +5 more
europepmc   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 966-978, October 2026.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Glycogen and Glycosylation: Friends or Foes? [PDF]

Biomolecules
Konada RSR, Osborn J, Mitra S.
europepmc   +1 more source

Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke

Glia, Volume 74, Issue 10, October 2026.
Chemogenetic activation of Gq signaling in microglia ahead of ischemic stroke reduces infarct size in mice. Seven days after stroke, Gq‐primed microglia in the penumbra show enhanced interferon responses, altered branching patterns, and reduced phagocytosis.
Lynn Bitar, Marie‐Luise Brehme, Charlotte Oldenburg, Sara Isla Cainzos, Michael G. Kaul, Tobias Mummert, Malte Borggrewe, Thomas G. Oertner, Tim Magnus   +8 more
wiley   +1 more source

Crystal structure of mouse DXO in complex with the UDP-N-acetylglucosamine cap and molecular mechanism for the decapping reactions. [PDF]

Nucleic Acids Res
Ullah N, Doamekpor SK, Tong L.
europepmc   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Structural basis of chondroitin sulfate backbone polymer synthesis. [PDF]

Nat Commun
Tehrani D, Cortiella-Valls N, Huang C, Chapla D, Zheng Z, Venkat A, O'Boyle B, Kannan N, Perez C, Moremen KW.   +9 more
europepmc   +1 more source

Multifaceted Suppression of Staphylococcal Virulence Phenotypes: In Vitro Study of a Cellular Status With Reduced Agr Activity and Impaired Biofilm

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Finding of in vitro S. aureus status with reduced Agr activity and impaired biofilm. ABSTRACT Anti‐quorum sensing (QS) therapy has been focused on to reduce the virulence of pathogenic bacteria. However, there is a risk that suppression of the staphylococcal QS Agr system might promote biofilm formation.
Nghi Bao Nguyen, Yuri Ushijima, Raiku Sekiya, Kazuya Morikawa, Le Thuy Thi Nguyen   +4 more
wiley   +1 more source

Excess glutamine rewires endothelial cell metabolism. [PDF]

Metabolomics
Kheradmand M, Zhou X, Okunrinboye F, Sriram G, Clyne AM.   +4 more
europepmc   +1 more source

Digital Twins for Offshore Wind Operation and Maintenance: A Review

Wind Energy, Volume 29, Issue 10, October 2026.
ABSTRACT Offshore wind has become a key focus for achieving carbon neutrality. However, offshore wind turbines face considerable operational and maintenance challenges due to harsh conditions and difficult access. Integrating digital twin technology helps support operation and maintenance activities.
Xiaomei Hu, Ravi Pandit, Yifan Zhao, Bernadin Namoano, Jiarong Hong   +4 more
wiley   +1 more source