Results 191 to 200 of about 97,609 (305)

Anthocyanins and betalains in evolution: Why mutual exclusion remains the best‐supported model

Plant Biology, EarlyView.
Anthocyanins and betalains are plant pigments produced through different biosynthetic pathways and are generally considered mutually exclusive. We examine claims of their co‐occurrence, arguing that methodological flaws and data misinterpretation have led to unsupported reports, and offer recommendations for more rigorous future research.
B. Pucker, M. I. Khan
wiley   +1 more source

How enzymes make the right choice during biosynthesis. [PDF]

Elife
Ramírez AS, Perez C.
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP-Galactose-4-Epimerase. [PDF]

Angew Chem Int Ed Engl
Browne WM, Pettinger J, Weckwerth T, Purkiss A, Lok SH, Penicaut L, Ogrodowicz R, Prema R, Kunzelmann S, Roustan C, Bineva-Todd G, Pieters S, Zappacosta F, Doherty AE, Oram I, Soudy C, Quinlan R, Redmond J, Kjaer S, House D, Mouilleron S, Bush JT, Schumann B.   +22 more
europepmc   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Enzymatic activities of proteins encoded by PmurB, PmurC, and PmurE involved in methanogen pseudomurein biosynthesis. [PDF]

Front Microbiol
Cha G, Lai Z, Wang S, Yang Q, Zhao P, Chen Y, Han W, Bai L.   +7 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression. [PDF]

Cardiovasc Res
Deiman FE, Arslan T, de Brouwer R, Henry I, Löfgren L, Cavallin A, Michopoulos F, Nilsson R, Henricsson M, Ahlstrom C, Davidsson P, Bomer N, Grote Beverborg N, van der Meer P.   +13 more
europepmc   +1 more source

MIB for the UDP-Lite Protocol

, 2008
Fairhurst, Godred, Renker, G.
core  

Post‐exercise ketone supplementation improves endurance performance and mitochondrial adaptations during an 8‐week endurance training intervention

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐eight trained males completed 8 weeks of supervised indoor cycling training, receiving post‐exercise and pre‐sleep ketone monoester (KE, n = 14) or isocaloric placebo (CON, n = 14). Both groups improved 30 min time‐trial performance with training, but KE achieved a 4% higher power output than CON at the end of the training
Ruben Robberechts, Youri Bekhuis, Myrthe Stalmans, Wout Lauriks, Martijn Kusters, Karim Taha, Thomas Rosseel, Guido Claessen, Chiel Poffé   +8 more
wiley   +1 more source