Results 211 to 220 of about 81,476 (261)
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The synthesis of UDP-galactosamine and UDP-N-acetylgalactosamine
Biochemical and Biophysical Research Communications, 1970Abstract A commercially available preparation of galactose-1-phosphateuridyl transferase was used in the synthesis of UDP-galactosamine and UDP-N-acetylgalactosamine. The method provides a relatively simple means for preparing these important biological materials in high yield and in an isotopic form of almost any desired specific radioactivity ...
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Synthesis of a Novel UDP-carbasugar as UDP-galactopyranose Mutase Inhibitor
Organic Letters, 2014The multistep synthesis of a novel UDP-C-cyclohexene, designed as a high energy intermediate analogue of the UDP-galactopyranose mutase (UGM) catalyzed isomerization reaction, is reported. The synthesis of the central carbasugar involved the preparation of a galactitol derivative bearing two olefins necessary for the construction of the cyclohexene ...
El Bkassiny, Sandy +4 more
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Steroid UDP glucuronosyltransferases
The Journal of Steroid Biochemistry and Molecular Biology, 1992The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
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The Journal of Organic Chemistry, 1999
For the enzymatic transfer of galactose, N-acetylglucosamine, and N-acetylgalactosamine, UDP-Gal (1), UDP-GlcNAc (2), and UDP-GalNAc (3) are employed, and UDP serves as a feedback inhibitor. In this paper the synthesis of the novel UDP-sugar analogues 4, 5, and 6 as potential transferase inhibitors is described.
A, Schäfer, J, Thiem
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For the enzymatic transfer of galactose, N-acetylglucosamine, and N-acetylgalactosamine, UDP-Gal (1), UDP-GlcNAc (2), and UDP-GalNAc (3) are employed, and UDP serves as a feedback inhibitor. In this paper the synthesis of the novel UDP-sugar analogues 4, 5, and 6 as potential transferase inhibitors is described.
A, Schäfer, J, Thiem
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Determination of UDP-glucuronyltransferase using UDP-[14C]glucuronic acid
Biochemical Pharmacology, 1975Abstract A method for the evaluation of UDPGT activity is proposed using [14C]UDPGA. Free UDPGA, glucuronide and aglycone were seperated on an Amberlite XAD2 column. This method is suitable for every substrate able to be bound to the resin such as phenolic compounds.
J M, Ziegler +3 more
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Molecular evolution and functional divergence of UDP-hexose 4-epimerases
Current Opinion in Chemical Biology, 2021Shinya Fushinobu
exaly
Synthesis and activity of UDP-GlcNAc and UDP-GalNAc analogues
2019UDP-GlcNAc and UDP-GalNAc are the most important Leloir substrates employed by glycosyltransferases (GTs). We are interested in two particular GTs: OGT and GalNAc-T2. The human O-GlcNAc transferase (hOGT) is a metal independent Leloir GT that transfers GlcNAc to Ser or Thr residues of intracellular proteins and peptides. hOGT is an essential enzyme for
Delso, J. Ignacio +4 more
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