Results 231 to 240 of about 211,061 (307)

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou, Nikolaos Ktenopoulos, Anastasios Apostolos, Christos Fragoulis, Panayotis Vlachakis, Paschalis Karakasis, Marios Sagris, Nikias Milaras, Maria Drakopoulou, Andreas Synetos, Ioannis Kyriazis, Ioannis Ioannidis, Costas Tsioufis, Konstantinos Toutouzas   +13 more
wiley   +1 more source

Multi-Omics Analysis Reveals Crucial Mechanisms by Which Shading Intensity Regulates Sugar Metabolism in Asparagus Stems. [PDF]

Plants (Basel)
Li Q, Qiu G, Lu X, Liu Z, Zhou X, Wang H, Luo F, Li M, Lu W, Jiang C, Zheng Y.   +10 more
europepmc   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, Volume 18, Issue 5, Page 669-677, May 2026.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Liver Transplantation Outcomes in Crigler‐Najjar Syndrome in Iran: A Single‐Center Retrospective Cohort Study Over 20 Years

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Crigler‐Najjar Syndrome (CNS) is a rare autosomal recessive disorder caused by uridine diphosphate glucuronosyltransferase (UGT1A1) deficiency, leading to unconjugated hyperbilirubinemia. Without treatment, patients are at high risk of kernicterus and irreversible neurological damage.
Sajad Teimoury, Zahra Beyzaei, Alireza Shamsaeefar, Kurosh Kazemi, Saman Nikeghbalian, Seyed‐Ali Malekhosseini, Bita Geramizadeh   +6 more
wiley   +1 more source

Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination. [PDF]

Plant Commun
Li G, Wen H, Zhou H, Liu Y, Yuan Z, Zhang H, Hu Z, Liu Z, Ma H, Chen Q, Chen G, Yao JL, Xu J, Chen J.   +13 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

A Blockchain‐Less Traceability System for Agriculture Using DAG, IPFS, and Serverless Deployments

International Journal of Network Management, Volume 36, Issue 3, May/June 2026.
ABSTRACT Ensuring transparency and integrity in agricultural data management is a critical challenge as the sector increasingly relies on advanced technologies. The primary problem is maintaining data traceability and security throughout the supply chain.
Antonio Villafranca, Igor Tasic, Victor Gallegos, Almudena Gimenez, Jesus Ochoa Rego, Juan Antonio Fernandez, Maria‐Dolores Cano   +6 more
wiley   +1 more source

Mechanism of Bacterial Arginine <i>N</i>‑Glycosylation: A Chemically Challenging Post-Translational Modification. [PDF]

ACS Catal
Piniello B, García-García A, Pietrucci F, Hurtado-Guerrero R, Rovira C.   +4 more
europepmc   +1 more source

Gene Expression Patterns Regulating Peanut Reproductive Phenology

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Peanut reproduction is foundational for crop yield, breeding, and evolution. However, gene regulation underlying peanut flowering pattern and timing has received limited attention. Cultivated peanut (Arachis hypogaea L.) shows two distinct flowering patterns between two subspecies, with ssp.
Carlos Henrique Cardon, Adnan Kivanc Corut, Ye Chu, Jason Wallace, Ran Hovav, Peggy Ozias‐Akins   +5 more
wiley   +1 more source

Ensemble-based detection of distributed denial-of-service attacks in IoT networks using majority decision mechanisms. [PDF]

Sci Rep
Cheng S, Feng X.
europepmc   +1 more source