Results 71 to 80 of about 97,609 (305)

La antinomia de la razón práctica como absurdum practicum

Filosofia Unisinos, 2016
Las antinomias de la razón ocupan un lugar destacado en el sistema crítico de Kant. El conflicto de la razón consigo misma es lo que despierta al Profesor de Königsberg del “sueño dogmático” y lo conduce a la elaboración del idealismo trascendental. Sin
Laura Alejandra Pelegrín
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Aplicabilidade e desempenho do protocolo de transporte SCTP [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.Nas pilhas de protocolos de rede típicas, como TCP/IP, a camada de rede oferece transmissão não confiável de ...
Pfützenreuter, Elvis
core  

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Emotion recognition and cognitive empathy deficits in adolescent offenders revealed by context-sensitive tasks

Frontiers in Human Neuroscience, 2014
Emotion recognition and empathy abilities require the integration of contextual information in real-life scenarios. Previous reports have explored these domains in adolescent offenders (AOs) but have not used tasks that replicate everyday situations.
Maria Luz eGonzalez-Gadea, Maria Luz eGonzalez-Gadea, Maria Luz eGonzalez-Gadea, Eduar eHerrera Murcia, Eduar eHerrera Murcia, Eduar eHerrera Murcia, Mario eParra, Mario eParra, Mario eParra, Mario eParra, Pedro eGomez Mendez, Sandra eBaez, Sandra eBaez, Sandra eBaez, Facundo eManes, Facundo eManes, Facundo eManes, Facundo eManes, Agustin eIbanez, Agustin eIbanez, Agustin eIbanez, Agustin eIbanez   +21 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

The Performance Comparison of Multiloop PID Controller on NCS Temperature Plant Based on UDP and TCP

Jurnal Rekayasa Elektrika
Hardware implementations of networked control systems (NCS) are still rarely found in various research publications so that technical issues, such as how to measure random delay and substitute it into the control equation, still need to be studied ...
Feriyonika Feriyonika, Tjan Swi Hong, Miftah Hasan Fuadi   +2 more
doaj   +1 more source

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, EarlyView.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

mBio, 2017
Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is
Liang Ma, Omar Salas, Kyle Bowler, Maor Bar-Peled, Amir Sharon   +4 more
doaj   +1 more source