Results 91 to 100 of about 211,061 (307)

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

open access: yes, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I   +2 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

open access: yesBMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang   +12 more
wiley   +1 more source

UDP-Glucose: A Potential Signaling Molecule in Plants?

open access: yesFrontiers in Plant Science, 2018
This perspective paper focuses on the most recent results suggesting a potential role for UDP-Glucose as a signaling molecule in plants. In animals, UDP-Glucose is well-established as an extracellular signaling molecule that is sensed by G-protein ...
Henry Christopher Janse van Rensburg   +1 more
doaj   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory   +13 more
wiley   +1 more source

Reseña de Property, Power and Politics: Why We Need to Rethink the World Power System. Jean-Philippe Robé. Bristol University Press, 2020

open access: yesSortuz
Property, Power and Politics: Why We Need to Rethink the World Power System es una de las contribuciones más ambiciosas del jurista francés Jean-Philippe Robé al debate contemporáneo sobre la relación entre derecho, economía y poder. El libro reconstruye
Ricardo Valenzuela
doaj   +1 more source

Performance of TCP/UDP under Ad Hoc IEEE802.11

open access: yes, 2003
TCP is the De facto standard for connection oriented transport layer protocol, while UDP is the De facto standard for transport layer protocol, which is used with real time traffic for audio and video.
Aboelaze, Mokhtar, Petrovic, Milenko
core   +1 more source

Real-time cross-layer design for large-scale flood detection and attack trace-back mechanism in IEEE 802.11 wireless mesh networks [PDF]

open access: yes, 2009
IEEE 802.11 WMN is an emerging next generation low-cost multi-hop wireless broadband provisioning technology. It has the capability of integrating wired and wireless networks such as LANs, IEEE 802.11 WLANs, IEEE 802.16 WMANs, and sensor networks.
Khan, S, Loo, KK
core   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples   +10 more
wiley   +1 more source

Towards an experimental account of argumentation: the case of the slippery slope and the ad hominem arguments

open access: yesFrontiers in Psychology, 2014
Argumentation is a crucial component of our lives. Although in the absence of rational debate our legal, political, and scientific systems would not be possible, there is still no integrated area of research on the psychology of argumentation ...
Marco eLillo-Unglaube   +3 more
doaj   +1 more source

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

open access: yesEpileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen   +4 more
wiley   +1 more source

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