Results 11 to 20 of about 14,737 (217)
Engineered Transformer Base Editor with Enhanced Editing Efficiency [PDF]
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +2 more sources
Ugi Four-Component Reactions Using Alternative Reactants
Molecules, 2023 The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
doaj +2 more sources
Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts [PDF]
Frontiers in Chemistry, 2019 We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts.
Alaa Zidan +5 more
openaire +7 more sources
Environmental Systems Research, 2020 Many studies have been conducted on the challenges underpinning the depletion and inaccessibility of urban green infrastructures (UGI) in cities of developed countries.
Sileshi Azagew, Hailu Worku
doaj +1 more source
China’s urban green innovation: Regional differences, distribution dynamics, and convergence
Chinese Journal of Population, Resources and Environment, 2023 Urban green innovation (UGI) is essential to environmental protection, ecological conservation, and high-quality economic growth. Using green patents, our study assessed the level of UGI of 287 Chinese cities at and above the prefecture level.
Yuting Xue +3 more
doaj +1 more source
Q&A: What are pathogens, and what have they done to and for us?
BMC Biology, 2017 Microbes are found on us, within us and around us. They inhabit virtually every environment on the planet and the bacteria carried by an average human, mostly in their gut, outnumber human cells. The vast majority of microbes are harmless to us, and many
Francois Balloux, Lucy van Dorp
doaj +1 more source
Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]
, 2013 Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
Cole, Ambrose R. +11 more
core +1 more source
Protein-Templated Hit Identification via an Ugi Four-Component Reaction [PDF]
, 2020 Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of building blocks via an irreversible reaction.
jennifer, herrmann +11 more
core +2 more sources
Espiral, 2019 La Ciudad de México constituye una vasta concentración de fuerza de trabajo y medios de producción que representa una formidable capacidad de extracción de ganancias, y requiere de una compleja gestión para su control. En los últimos años, la batalla por
Adrián Flores
doaj +1 more source
Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry [PDF]
, 2022 The possibility of harnessing the photoactivity of isocyanides in the development of metal-free Ugi-like visible light photo-triggered multicomponent transformations has been reported herein.
Mariateresa Giustiniano +4 more
core +1 more source