Results 31 to 40 of about 7,375 (185)

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

Angewandte Chemie, EarlyView.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Application of heterocyclic aldehydes as components in Ugi–Smiles couplings

Beilstein Journal of Organic Chemistry, 2016
Efficient one-pot Ugi–Smiles couplings are reported for the use of furyl-substituted aldehyde components. In the presence of these heterocyclic aldehydes, reactions tolerated variations in amine components and led to either isolated N-arylamide Ugi ...
Katelynn M. Mason, Michael S. Meyers, Abbie M. Fox, Sarah B. Luesse   +3 more
doaj   +1 more source

The effectiveness of urban green infrastructure in reducing surface urban heat island

Ain Shams Engineering Journal, 2022
In the era of the devastating impacts of climate change, many cities around the world make strenuous efforts to find suitable and sustainable adaptation strategies to address the climatic dangers.
Maryam F. Abdulateef, Hoda A. S. Al-Alwan   +1 more
doaj   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

The Jekyll and Hyde Nature of Tetrazoles in Polymer Science: From Intrinsic Electronic Duality to Programmable Macromolecular Function

Angewandte Chemie International Edition, EarlyView.
Tetrazoles are reframed as substitution‐programmable heterocycles rather than static functional groups in polymer chemistry. By linking electronic identity to synthetic strategy and polymer architecture, this mini‐review establishes a design framework for translating tetrazole duality into predictable macromolecular function.
Meryem S. Akdemir, Hatice Mutlu
wiley   +1 more source

Ugi Four-Component Reactions Using Alternative Reactants

Molecules, 2023
The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
doaj   +1 more source

One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification

Biotechnology and Bioengineering, EarlyView.
One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal, Catarina Domingos, André Nascimento, José Mendes, Afonso B. Ruiz, Ana Margarida Gonçalves Carvalho Dias, Luisa M. Ferreira, Cristina Peixoto, Ana Cecília Afonso Roque   +8 more
wiley   +1 more source

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts [PDF]

Frontiers in Chemistry, 2019
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts.
Alaa Zidan, Alaa Zidan, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm   +5 more
openaire   +4 more sources

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Environmental ecosystem services assessment based on urban green infrastructure structure indicators with case study in Shanghai [PDF]

E3S Web of Conferences, 2019
Urban green infrastructure (UGI) attracts much interest because they could provide urban ecosystem services (UES). Among all various methodologies, the UGI structure-based modelling is favored for advantages in physiological mechanisms.
Zhao Liang
doaj   +1 more source