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Catalytic Three-Component Ugi Reaction [PDF]
Angewandte Chemie - International Edition, 2008 Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst.
Subhas Chandra Pan, Benjamin List
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Cyclic Imines in Ugi and Ugi-Type Reactions
ACS Combinatorial Science, 2020Ugi four-component reactions (U-4CRs) are widely recognized as being highly efficient for the synthesis of pseudopeptides. However, the products of these reactions are not so interesting as drug candidates because they are not conformationally restricted enough for a potent interaction with biological targets.
Ahmad Shaabani +2 more
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An Ugi Reaction in the Total Synthesis of (−)-Dysibetaine
Angewandte Chemie - International Edition, 2009AbstractEinen einfachen Zugang zu (−)‐Dysibetain bietet eine elfstufige Reaktion ausgehend von L‐Äpfelsäure (siehe Schema). Der Schlüsselschritt ist eine einzigartige Vier‐Zentren‐drei‐Komponenten‐Ugi‐Cyclisierung, bei der eine Estereinheit als Carbonsäurekomponente fungiert.
Yoshihisa Kobayashi
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Ugi Reaction with Isocyanoindoles.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
M. A. Mironov +3 more
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The Catalytic Enantioselective Ugi Four-Component Reactions [PDF]
Angewandte Chemie - International Edition, 2018 Finally stereoselective: Enantioselective variations have been developed for many multicomponent reactions; however, it has been missing for the Ugi four-component reaction. This has now changed with the discovery of an efficient catalytic enantioselective variant for the four-component reaction of isocyanides, primary amines, aldehydes or ketones, and
Shabnam Shaabani, Alexander Domling
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Tetrahedron, 2001
Abstract A variety of hydantoinimide and tetrazole derivatives was prepared by combining two different Ugi reactions (U-4CRs) in solid and liquid phases.
Ivar Ugi
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Abstract A variety of hydantoinimide and tetrazole derivatives was prepared by combining two different Ugi reactions (U-4CRs) in solid and liquid phases.
Ivar Ugi
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Seven-component reactions by sequential chemoselective Ugi–Mumm/Ugi–Smiles reactions
Chemical Communications, 2010A seven-component reaction was accomplished by utilizing the different chemoselectivities of the Ugi-Mumm and the Ugi-Smiles reaction. The sequential multicomponent reactions led to highly diverse peptide and glycopeptide like structures.
Sebastian, Brauch +2 more
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Versatile Protecting-Group Free Tetrazolomethane Amine Synthesis by Ugi Reaction [PDF]
ACS Combinatorial Science, 2016 The use of ammonia in the Ugi reaction is often problematic due to low yields and multiple side reactions. Here, we report the use of ammonia in the tetrazole Ugi variation providing a clean, good-to-high yielding reaction, especially with ketones as oxo
Justyna Kalinowska-Tłuścik +2 more
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Synthesis of Thiomorpholines by an Intramolecular Ugi Reaction.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
MARCACCINI, STEFANO +4 more
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Skeletal Diversity by Ugi Four-Component Coupling Reaction and Post-Ugi Reactions
HETEROCYCLES, 2007Here we report a strategy to alter the skeletal complexity of Ugi four-component coupling reaction products by using allylations followed by ring-closing metathesis. Principal component analysis is also performed for these compounds.
Masato Oikawa +2 more
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