Results 51 to 60 of about 12,153 (191)

Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens

Journal of Translational Medicine, 2018
Backgrounds UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response.
Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Xiao-Ping Chen   +12 more
doaj   +1 more source

UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults

Journal of Clinical and Translational Hepatology, 2021
Bilirubin encephalopathy/kernicterus is very rare in adults. This study is aimed to investigate the clinical manifestations and genetic features of two patients with UGT1A1-related kernicterus.Sanger sequencing analysis was performed to identify UGT1A1 gene mutations in the patients and their families.
Bai, Jie, Li, Lu, Liu, Hui, Liu, Shuang, Bai, Li, Song, Wenyan, Chen, Yu, Zheng, Sujun, Duan, Zhongping   +8 more
openaire   +2 more sources

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source

Evolution of the activity of UGT1A1 throughout the development and adult life in a rat

, 2005
Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance.
Cantarino Aragón, María Helena, Arahuetes Portero, Rosa María, Ortiz, Agustín, Bustamante, Nelia, Cubero Palero, Francisco Javier   +4 more
core   +1 more source

Effects of Shengjiangxiexin decoction on irinotecan-induced toxicity in patients with UGT1A1*28 and UGT1A1*6 polymorphisms

Journal of Traditional Chinese Medicine, 2017
To evaluate the efficacy of Shengjiangxiexin decoction (SXD), prepared with a formula from Traditional Chinese Medicine (TCM), in reducing irinotecan-induced hematological and gastrointestinal toxicities in patients with UDP-glucuronosyltransferase (UGT)1A1*28 and UGT1A1*6 polymorphisms.This clinical trial included 115 patients receiving irinotecan ...
Bo, Deng, Liqun, Jia, Huangying, Tan, Yanni, Lou, Xue, Li, Yuan, Li, Lili, Yu   +6 more
openaire   +2 more sources

Do Gene Polymorphisms Play a Role in Newborn Hyperbilirubinemia?

Balkan Journal of Medical Genetics
Polymorphisms of the uridine-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene, hepatic solute carrier organic anion transporter 1B1/B3 (SLCO1B1/3) gene, and glutathione S-transferase (GST) gene have been associated with significant hyperbilirubinemia ...
Hakan N, Aydin M, Ceylaner S, Dilli D, Zenciroğlu A, Okumuş N   +5 more
doaj   +1 more source

Cost-effectiveness of UGT1A1 testing.

, 2018
Cost-effectiveness of UGT1A1 testing.
Mikyung Kelly Seo (5793935), John Cairns (352167)   +1 more
core   +1 more source

A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer

, 2019
International audienceINTRODUCTION: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region.
Anon, Benjamin, Guyétant, Serge, Regnault, David, Godart, Bruno, Perray, Clémence, Orain, Isabelle, Tallet, Anne, Lecomte, Thierry, Ouaïssi, Mehdi, Pages, Jean-Christophe, Caulet, Morgane, Barin-Le Guellec, Chantal   +11 more
core   +1 more source

국소진행성 직장암에서 Irinotecan을 이용한 술전보강화학방사선치료 시 UGT1A1 유전자 다형태의 유용성 [PDF]

, 2007
Purpose: Irinotecan (CPT-11) is hydrolyzed to an active SN-38, which is further detoxicated to SN-38G through conjugation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzymes. There are many reports that UGT1A1 polymorphisms are associated
전, 미선, 오, 승엽, 서, 광욱, 김, 영배   +3 more
core   +1 more source

UGT1A1 polymorphisms as a pharmacogenetic markers for prediction of irinotecan-induced toxicities in metastatic colorectal cancer [PDF]

, 2019
Cilj ovog rada je bio napraviti pregled trenutnog statusa UGT1A1 polimorfizama kao farmakogenetičkih biljega za predviđanje toksičnosti na irinotekansku kemoterapiju u bolesnika s metastatskim kolorektalnim karcinomom.
Mirta Zekan Vučetić, Iva Kirac, Ramić, Snježana, Snježana Ramić, Zekan Vučetić, Mirta, Žigman, Tamara, Petra Vuković, Kirac, Iva, Vuković, Petra, Tamara Žigman   +9 more
core   +1 more source