Results 71 to 80 of about 12,153 (191)

miR-452 Reverses Abnormal Glycosylation Modification of ERα and Estrogen Resistance in TNBC (Triple-Negative Breast Cancer) Through Targeting UGT1A1

Frontiers in Oncology, 2020
Background: The breast epithelial cells in patients with triple-negative breast cancer (TNBC) actually have specific estrogen receptor (ER) expression, and the abnormal glycosylation of UGT1A1 in TNBC cells resulted in abnormal expression and function of
Yan Li, Yidong Zhou, Feng Mao, Songjie Shen, Bin Zhao, Yali Xu, Yan Lin, Xiaohui Zhang, Xi Cao, Ying Xu, Chang Chen, Jinqian Zhang, Qiang Sun   +12 more
doaj   +1 more source

Should We Consider Mutation Analysis in Evaluating the Prolonged Jaundice of Newborn Infants? [PDF]

Neonatal Medicine
Purpose Uridine diphosphate glucuronosyltransferase 1A isoform 1 (UGT1A1) is a crucial enzyme in bilirubin metabolism. Mutations in this gene cause prolonged unconjugated hyperbilirubinemia in infants.
Young Don Kim
doaj   +1 more source

Investigation of vascular invasion and genetic polymorphisms of DPD IVS14+1 G>A, UGT1A1 3156 G>A, and UGT1A1 28 tandem repeats in colorectal cancer patients in Taiwan

, 2012
In the present study, multiple chemotherapeutic agent-related genetic polymorphisms, including dihydropyrimidine dehydrogenase (DPD) IVS14+1 G>A, UGT1A1 3156 G>A, and UDP-glucuronosyltransferase (UGT)1A1 28 tandem repeats, were analyzed in patients with ...
Ming-Yii Huang;Meng-Lin Huang;Jaw-Yuan Wang;Shiu-Ru Lin
core  

Is there diversity amongUGT1A1polymorphism in Japan

World Journal of Gastrointestinal Oncology, 2012
To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan.We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi (southern part of Japan) and Akita (northern part of Japan) prefectures.
Michiya, Kobayashi, Shoichi, Hazama, Kenichi, Takahashi, Koji, Oba, Naoko, Okayama, Mitsuaki, Nishioka, Yuji, Hinoda, Masaaki, Oka, Ken, Okamoto, Hiromichi, Maeda, Daisuke, Nakamura, Junichi, Sakamoto, Hideyuki, Mishima   +12 more
openaire   +2 more sources

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

, 1993
UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1.
Bout, A., Duncan, A. M., Bosma, P., Chowdhury, J. R., Jansen, P. L., Schurr, E., van Es, H. H., Anderson, L., Liu, J., Oude Elferink, R.   +9 more
core   +1 more source

Pharmacogenetic Practice of Anticancer Drugs: Multiple Approaches for an Accurate and Comprehensive Genotyping

Pharmacogenomics and Personalized Medicine, 2023
Cristina Montrasio,1 Stefania Cheli,1 Emilio Clementi2,3 1Unit of Clinical Pharmacology, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy; 2Clinical Pharmacology Unit, Department of Biomedical and Clinical Sciences, L.
Montrasio C, Cheli S, Clementi E
doaj  

UGT1A1*28 polymorphism and the risk of toxicity and disease progression in patients with breast cancer receiving sacituzumab govitecan

Cancer Medicine
Background Sacituzumab govitecan (sacituzumab) emerged as an important agent in metastatic and locally recurrent HER2‐negative breast cancer treatment. UGT1A1 polymorphisms have also been shown to predict sacituzumab toxicity.
Megan H. Wong, Veronica C. Jones, Wai Yu, Linda D. Bosserman, Sayeh M. Lavasani, Niki Patel, Mina S. Sedrak, Daphne B. Stewart, James R. Waisman, Yuan Yuan, Joanne E. Mortimer   +10 more
doaj   +1 more source

Clinical Outcomes of Patients with Peritoneal Metastasis-Only Colorectal Cancer Treated with First-Line Bevacizumab and FOLFIRI Through Irinotecan Dose Escalation According to UGT1A1 Polymorphism: Compared to Liver Metastasis-Only, and Lung Metastasis-Only

Cancer Management and Research, 2022
Ching-Chun Li,1 Tsung-Kun Chang,1,2 Yen-Cheng Chen,1,3 Hsiang-Lin Tsai,1,2 Ching-Wen Huang,1,2 Wei-Chih Su,1,3 Cheng-Jen Ma,1,3 Tzu-Chieh Yin,1,4,5 Po-Jung Chen,1 Jaw-Yuan Wang1– 3,6– 8 1Division of Colorectal Surgery, Department of Surgery, Kaohsiung ...
Li CC, Chang TK, Chen YC, Tsai HL, Huang CW, Su WC, Ma CJ, Yin TC, Chen PJ, Wang JY   +9 more
doaj  

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD

Molecules, 2017
Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation.
Ying Xie, Sonia R. Miranda, Janelle M. Hoskins, Roy L. Hawke   +3 more
doaj   +1 more source

Clinical Implication of UGT1A1 Promoter Polymorphism for Irinotecan Dose Escalation in Metastatic Colorectal Cancer Patients Treated with Bevacizumab Combined with FOLFIRI in the First-line Setting

Translational Oncology, 2015
PURPOSE: This study aimed to identify the efficacy and toxicity of the FOLFIRI regimen (fluorouracil, leucovorin, and irinotecan) with irinotecan dose escalation plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer (mCRC) via ...
Chien-Yu Lu, Ching-Wen Huang, I-Chen Wu, Hsiang-Lin Tsai, Cheng-Jen Ma, Yung-Sung Yeh, Se-Fen Chang, Meng-Lin Huang, Jaw-Yuan Wang   +8 more
doaj   +1 more source