Results 81 to 90 of about 12,153 (191)

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses [PDF]

, 2012
Background: A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011.
Hartley, J.A., MacPherson, I.R.J., Masanori Miwa, Hartley, JM, Jones, K, Crawford Donna, Saito Tomohisa, Evans, TRJ, Hartley, JA, Jones Keith, MacPherson, IRJ, Abe Masaichi, Crawford, D, Jones, K., D Alan Anthoney, John M Hartley, Saito, T., Twelves, C., Hartley Janet A, Anthoney, D.A., Christopher Twelves, Anthoney, DA, Miwa, M., Miwa Masanori, TRJ Evans, Evans, T.R.J., Naik, J, Jay Naik, Donna Crawford, Keith Jones, Abe, M., Saito, T, Tomohisa Saito, Abe, M, Naik Jay, Naik, J., MacPherson Iain RJ, Evans TRJ, Hartley, J.M., Hartley John M, Masaichi Abe, Miwa, M, Twelves, C, Crawford, D., Anthoney D, Janet A Hartley, Twelves Christopher, Iain RJ MacPherson   +47 more
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The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography

, 2017
Background: Uridine diphosphate glycosyltransferases 1A1 (UGT1A1) plays an essential role in detoxification and excretion of several endogenous and exogenous compounds.
Barbara Zulus, Wilfried Renner, Gerda Grünbacher, Winfried März, Marcus E. Kleber   +4 more
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A Case of Adult Hereditary Spherocytosis Concomitant with Gilbert Syndrome Caused by Mutations in SPTB and UGT1A1

Journal of Inflammation Research
Yang Gou,1,2 Ping Wang,1,2 Wucheng Yang,1,2 Yimei Feng,1,2 Xiangui Peng,1,2 Hong Liu,1,2 Shuiqing Liu,1,2 Xi Zhang1,2 1Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, People’s Republic of China; 2Chongqing ...
Gou Y, Wang P, Yang W, Feng Y, Peng X, Liu H, Liu S, Zhang X   +7 more
doaj  

The complexes of UGT1A1 with coenzyme and substrates.

, 2019
Pairs of UDPGA and substrates for wild-type UGT1A1 are as follows: A: UDPGA and AAP; B: UDPGA and E2; C: UDPGA and bilirubin; and D: UDPGA and SN-38.
Hisahide Nishio (7871633), Mika Ohta (226941), Nobutaro Ban (3528680), Atsuko Takeuchi (2315950), Toshiyuki Sakaeda (17393), Yutaka Takaoka (226939), Aki Sugano (4603942), Takashi Suzuki (8491), Kenji Miura (41797), Daisuke Kobayashi (448930), Takuji Kimura (7871630), Juichi Sato (3843736)   +11 more
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UGT1A1 catalyzed the demethoxycurcumin-O-glucuronidation, and expression of UGT1A1 and efflux transporters in HeLa1A1 cells.

, 2019
(A) Kinetic profiles for demethoxycurcumin-O-glucuronides (G1 and G2) (0.5–40 μM) by UGT1A1; (B) Kinetic profiles for demethoxycurcumin-O-glucuronides (G1 and G2) (0.5–40 μM) by HeLa1A1 cell lysate; In each panel, the insert figure showed the ...
Zhihong Yao (693768), Shishi Li (6786503), Xiaojian Zhang (506598), Beibei Zhang (509356), Jinjin Xu (4063582), Jing Yang (13969), Zifei Qin (5643410), Xinsheng Yao (374401), Frank J. Gonzalez (92945)   +8 more
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Relationship betweenUGT1A1gene polymorphisms and toxicity of irinotecan-based chemotherapy in colorectal cancer

Zhongguo aizheng zazhi, 2014
Background and purpose: Uridine diphosphoglucu-ronosyl transferase 1A1 (UGT1A1) is an important enzyme for metabolism of irinotecan. The activity of UGT1A1 enzyme was significantly affected by the gene polymorphism.
周琰, 庄荣源, 陈朴, 谈绮文, 张春燕, 郭玮, 刘天舒, 潘柏申   +7 more
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Genetic variation in UGT1A1 is not associated 1 with altered liver 2 biochemical parameters in healthy volunteers participating in 3 bioequivalence trials

Esta tabla corresponde a los datos utilizados para el artículo "Genetic variation in UGT1A1 is not associated with altered liver biochemical parameters in healthy volunteers participating in bioequivalence trials ...
Novalbos, Jesús, Zubiaur, Pablo, Abad-Santos, Francisco, Rodríguez-Lopez, Andrea, Soria-Chacartegui, Paula, Ochoa, Dolores, Navares-Gómez, Marcos, Román, Manuel, de Miguel, Alejandro, González-Iglesias, Eva, Martín-Vilchez, Samuel   +10 more
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UGT1A1 gene promoter-region variants: Pakistani cohort

This primary exploratory study was performed for the identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter-region variants (UGT1A1*1, *28, *36 and *37) in adults of Pakistani origin. Genomic DNA extraction was performed to find out the
Anser, Sardar
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IRINOTECANTOXICITY RELATED TO GILBERT´S SYNDROME   - COMPARISON OF THREE METHODS FOR GENOTYPING OF UGT1A1 (TA)n

, 2009
Gilbert’s syndrome (GS) occurs in approximately 10% of the European population. The most common cause is homozygosity for UGT1A1*28, which is a TA repeat expansion in the promoter of UGT1A1.
Fredriksson, Lena
core   +2 more sources

Генний поліморфізм G211A гену UGT1A1 та пролонгована неонатальна жовтяниця [PDF]

, 2016
Неонатальна гіпербілірубінемія є поширеною проблемою серед новонароджених дітей в усьому світі. В останні роки з'явилися повідомлення про роль генного поліморфізму в розвитку неонатальних жовтяниць.
Мазур, О. Г, Яблонь, О. С.   +1 more
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