Results 91 to 100 of about 12,153 (191)

Dose-Dependent Association between UGT1A1*28 Genotype and Irinotecan-Induced Neutropenia: Low Doses Also Increase Risk

, 2010
Purpose: A previous meta-analysis showed that the association between the UGT1A1*28 genotype and irinotecan-induced neutropenia was influenced by irinotecan dose and that the risk of neutropenia was similar at low doses for patients with all genotypes ...
Qi Yu, Cheng Guo, Qi Pei, Zhe-Yi Hu
core   +1 more source

UGT1A1 Gene [PDF]

, 2020
openaire   +1 more source

The role of UGT1A1 polymorphism in the management of colorectal cancer

Oncology Reviews
Colorectal cancer is a leading cause of cancer related deaths among patients worldwide, necessitating the development of more effective and tolerable therapies. Topoisomerase I inhibitors such as Irinotecan are integral components of chemotherapy regimens used in the management of colorectal, as well as esophageal, gastric, biliary tract, pancreatic ...
Elham Babadi, Kamran Roudini, Kianmehr Aalipour, Olatunji B. Alese   +3 more
openaire   +3 more sources

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

CPT: Pharmacometrics & Systems Pharmacology
Optimal dosing in pregnant and lactating women requires an understanding of the pharmacokinetics in the mother, fetus, and breastfed infant. Physiologically‐based pharmacokinetic (PBPK) modeling can be used to simulate untested scenarios and hence ...
Jia Ning, Amita Pansari, Karen Rowland Yeo, Aki T. Heikkinen, Catriona Waitt, Lisa M. Almond   +5 more
doaj   +1 more source

Pre‐Therapeutic UGT1A1 Genotyping in Breast Cancer Patients Receiving Sacituzumab Govitecan to Improve Safety: A Meta‐Analysis and Recommendation

Clinical and Translational Science
Pre‐therapeutic UGT1A1 genotyping is increasingly performed in patients receiving irinotecan, as its active metabolite SN‐38 is primarily cleared through UGT1A1‐mediated glucuronidation.
Tessa Goedhart, Henk‐Jan Guchelaar
doaj   +1 more source

UGT1A1*28 Allele [PDF]

, 2020
openaire   +1 more source

ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the intestine ...
KATAOKA, RYUJI, MORITA, EMI, KONDO, TAKAAKI, HAMAJIMA, NOBUYUKI, KIMATA, AKIKO, WAKAI, KENJI, HISHIDA, ASAHI, HIROSAWA, NAOKO, OKADA, RIEKO, UEYAMA, JUN, KAWAI, SAYO, NAITO, MARIKO, YAMAMOTO, KANAMI   +12 more
core  

UGT1A1 Polymorphism Positive [PDF]

, 2020
openaire   +1 more source

Clinical Implications of <i>UGT1A1</i> Polymorphisms in Anticancer Therapy: An Updated Review. [PDF]

Pharmaceutics
Vitale SR, Drago M, Martorana F, Conti C, Massimino M, Stella S, Tomarchio C, Vigneri P, Manzella L.   +8 more
europepmc   +1 more source

Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer. [PDF]

PLoS One
Zhou C, Ning Q, Jin X, Li Y, Lin Y, Lin J, Zheng J, Huang Y, Wang W, Liu Z, Lu L.   +10 more
europepmc   +1 more source