Results 61 to 70 of about 12,153 (191)

Dose-Limiting Toxicities and the Maximum Tolerated Dose of Irinotecan Based on UGT1A1 Genotypes: A Systematic Review

Pharmaceutics
Background/Objectives: Irinotecan is used in monotherapy or combined with other drugs for treating different cancer streams. SN-38, the active metabolite of irinotecan, is 70% inactivated by the uridine diphosphate (UDP) glucuronosyltransferase family 1 ...
Xando Díaz-Villamarín, María Teresa Nieto-Sánchez, María Martínez-Pérez, Paula Novo-González, Emilio Fernández-Varón, Alicia Torres-García, Beatriz González Astorga, Isabel Blancas, José Cabeza-Barrera, Rocío Morón   +9 more
doaj   +1 more source

Severe irinotecan-induced toxicity in a patient withUGT1A1*28andUGT1A1*6polymorphisms

World Journal of Gastroenterology, 2013
Many studies have demonstrated the impact of UGT1A1 on toxicity of irinotecan. In particular, patients bearing UGT1A1 28 (TA 7/7) have a higher risk of severe neutropenia and diarrhea. Based on this, prescribers of irinotecan are advised that patients with UGT1A1 28 (TA 7/7) should start with a reduced dose of irinotecan, although a particular dose is ...
Jian-Ming, Xu, Yan, Wang, Fei-Jiao, Ge, Li, Lin, Ze-Yuan, Liu, Manish R, Sharma   +5 more
openaire   +2 more sources

An Epileptic Patient with Recurrent Hyperbilirubinemia Caused by Gilbert Syndrome

Case Reports in Gastroenterology, 2020
Gilbert syndrome (GS) is characterized by intermittent indirect bilirubin elevation. Several antiepileptic drugs (AEDs) impair the liver function to different degrees, such as valproic acid, lamotrigine, phenobarbital, phenytoin, and carbamazepine ...
Yaoyao Zhang, Yongli Jiang, Fang Yuan, Changgeng Song, Zhihan Zhao, Wen Jiang   +5 more
doaj   +1 more source

Polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 are not associated with osteoporosis in artificial menopausal Japanese women

, 2015
Introduction : Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis.
Megumi Yokota, Takeshi Makabe, Kensuke Sakai, Kazuya Makita, Takashi Iwata, Mariko Ogawa, Daisuke Aoki, Tomoko Akahane, Wataru Yamagami, Shigehisa Yanamoto, Nobuyuki Susumu, Kouji Banno, Akira Hirasawa, Yuko Horiba, Ryota Deshimaru   +14 more
core   +1 more source

Polymorphisms of UGT1A1*6, UGT1A1*27 & UGT1A1*28 in three major ethnic groups from Malaysia.

The Indian journal of medical research, 2013
Genetic polymorphisms of uridine diphosphate glucuronyltransferase 1A1 (UGT1A1) have been associated with a wide variation of responses among patients prescribed with irinotecan. Lack of this enzyme is known to be associated with a high incidence of severe toxicity.
L K, Teh, H, Hashim, Z A, Zakaria, M Z, Salleh   +3 more
openaire   +1 more source

Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome

Kaohsiung Journal of Medical Sciences, 2019
Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome ...
May‐Jen Huang, Yi‐Chun Chen, Yang‐Yang Huang, Sien‐Sing Yang, Pei‐Lain Chen, Ching‐Shan Huang   +5 more
doaj   +1 more source

Association of UGT1A1 gene variants, expression levels, and enzyme concentrations with 2,3,7,8-TCDD exposure in individuals exposed to Agent Orange/Dioxin

Scientific Reports
Among the congener of dioxin, 2,3,7,8-TCDD is the most toxic, having a serious long-term impact on the environment and human health. UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in the detoxification and excretion of endogenous and ...
Ha Van Quang, Nguyen Ba Vuong, Bui Ngoc Linh Trang, Nguyen Linh Toan, Hoang Van Tong   +4 more
doaj   +1 more source

Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1

BMC Infectious Diseases, 2017
Background Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A).
Hiroki Yagura, Dai Watanabe, Hiroyuki Kushida, Kosuke Tomishima, Hiroaki Togami, Atsushi Hirano, Masaaki Takahashi, Kazuyuki Hirota, Motoko Ikuma, Daisuke Kasai, Yasuharu Nishida, Munehiro Yoshino, Kunio Yamazaki, Tomoko Uehira, Takuma Shirasaka   +14 more
doaj   +1 more source

Life-threatening toxicity in a patient with UGT1A1*6 heterozygous polymorphism after irinotecan-based chemotherapy: a case report

, 2014
Polymorphism of the UGT1A1 gene is known to play an important role in irinotecan pharmacokinetics and severe toxicity. A 71-year-old man with lung cancer (squamous cell carcinoma cT2aN3M0 stage IIIB) received irinotecan and cisplatin with concurrent ...
Hasegawa, Yoshinori, Kohno, Shigeru, Ogawara, Daiki, Senju, Hiroaki, Nakamura, Yoichi, Motoshima, Kohei, Honda, Takuya, Fukuda, Minoru, Nakatomi, Katsumi, Mizoguchi, Kousuke, Ashizawa, Kazuto, Takemoto, Shinnosuke   +11 more
core  

Assessment of the clinical significance of a UGT1A1 gene variant in affecting phototherapy response and long-term outcomes in neonatal hyperbilirubinemia

The Journal of Maternal-Fetal & Neonatal Medicine
Objective Phototherapy is the standard treatment, but its efficacy can vary among neonates, prompting interest in genetic factors, particularly UGT1A1 gene variants.
Shuai Fu, Xue Yang, Lin Pei, Xiaoman Wan, Yue Jiang, Yingying Kang, Hesheng Chang   +6 more
doaj   +1 more source