Results 101 to 110 of about 2,160 (157)

Development of novel trispecific immunoligands (triplebodies) to retarget natural killer cells against chronic lymphocytic leukemia [PDF]

, 2016
Chronic lymphocytic leukemia of B cells (B-CLL or CLL) involves malignant transformation of mature B lymphocytes and is characterized by accumulation of CD19+ CD5+ monoclonal B cells.
Vyas, Maulik
core  

Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature

Hereditas
Background Breast cancer (BRCA) is a malignancy originating in the breast cells, characterized by a poor overall survival rate. Post-resection, chemotherapy is commonly recommended as a primary therapeutic approach; however, its efficacy remains limited.
Zhaofeng Ma, Man Zheng, Pulin Liu
doaj   +1 more source

Identifying subtypes and developing prognostic models based on N6-methyladenosine and immune microenvironment related genes in breast cancer

Scientific Reports
Breast cancer (BC) is the most prevalent cancer in women globally. The tumor microenvironment (TME), comprising epithelial tumor cells and stromal elements, is vital for breast tumor development.
Lizhao Wang, Jianpeng Li, Nan Mei, Heyan Chen, Ligang Niu, Jianjun He, Ru Wang   +6 more
doaj   +1 more source

Epigenetic modulation of NKG2D ligands enhances NKG2D-CAR T cell efficacy in neuroblastoma. [PDF]

J Transl Med
Navarro-Zapata A, De Santisteban MO, Regojo-Zapata RM, Ibáñez-Navarro M, Clares-Villa L, de la Hoz M, Romero A, Mestre-Durán C, Al-Akioui Sanz K, Bareke H, Naharro S, Minguillón J, Pertíñez L, Riestra N, Masot M, Martín-Cortázar C, Aguirre-Portolés C, Ferreras C, Mañas A, Pérez-Martínez A, Casanova LF.   +20 more
europepmc   +1 more source

Regulation of the NKG2D stress ligands MICA, MICB and ULBP2 in proliferating and senescent tumor cells

, 2015
Das maligne Melanom stellt die tödlichste Form aller Hautkrebserkrankungen dar und entsteht durch eine maligne Transformation der Melanozyten. Melanomzellen können durch zytotoxische Lymphozyten, wie NK Zellen und T Zellen als entartet erkannt und ...
Baingo, Jolanthe
core  

Nuclear EGFR Block Expression of MHC Class-I Related Genes Necessary for Natural Killer Cell Recruitment and Cytotoxicity [PDF]

Nuclear Epidermal Growth Factor Receptor (nEGFR) driven triple negative breast cancer (TNBC) can exhibit therapeutic resistance and immune evasion in vivo, making treatment difficult.
Crane, Sara
core   +1 more source

Combinatorial therapy with resveratrol sensitizes glioblastoma to NKG2D CAR-T cells. [PDF]

Front Immunol
Liang W, Tang Y, Saliu MA, Salisu MD, Chen C, Xu Z, Xu S, Liu M, Wan X.   +8 more
europepmc   +1 more source

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells. [PDF]

Front Oncol
Ouyang Y, Qin Y, Zhang Q, Zhu P, Zhu H.
europepmc   +1 more source

NKGD2 Ligands (NKG2DLs) in Breast Cancer: In Silico Analysis and Narrative Review. [PDF]

Int J Mol Sci
Peña-López J, Gámez-Pozo A, Trilla-Fuertes L, Becerril-Gómez F, Mendiola M, Heredia V, Yébenes L, Castelo B, Martínez-Marín V, Espinosa E, Zamora P, Alba-Bernal A, Aguirre-Portolés C, Pérez-Martínez A.   +13 more
europepmc   +1 more source

EVOLVE platform, a trispecific T cell engager with integrated CD2 costimulation, for the treatment of solid and hematologic tumors. [PDF]

Proc Natl Acad Sci U S A
Sergeeva OA, Jin G, Sarkar M, Zeiger J, Dhindwal S, Chin SS, Abulizi A, Lai Z, Brown C, DeMaria WG, Ryan D, An X, Karp HJ, Teran E, Yuan C, Klaskin D, Reeve TA, Yu GK, Tam EM, Kaech SM, Preyer M, Matis L, Fine JS, Martomo SA, Myers JS.   +24 more
europepmc   +1 more source