Results 91 to 100 of about 2,160 (157)

A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner

, 2018
Natural killer group 2D (NKG2D), an activating receptor on natural killer (NK) cells and a subset of T cells, recognizes stress-inducible proteins, including MICA and ULBP2, which are present on infected or transformed cells.
Štefan Bálint, Filipa B. Lopes, Davis, Daniel M, Balint, Stefan, Daniel M. Davis, Lopes, Filipa B, Lopes, Filipa   +6 more
core   +1 more source

Regulation of NKG2D-ligand cell surface expression by intracellular calcium after HDAC-inhibitor treatment

, 2013
In this study we demonstrate that histone deacetylase (HDAC)-inhibitor mediated cell surface expression of the structural different NKG2D-ligands MICA/B and ULBP2 is calcium-dependent.
Hagemann-Jensen, Michael Henrik, Skov, Søren, Jensen, Helle, Lauridsen, Felicia Kathrine Bratt   +3 more
core   +1 more source

Methylation analysis of HLA-A, ULBP2 and ULBP3 in colorectal cancer cells

, 2011
Zentrale Fragestellung der Arbeit war es, eine mögliche funktionelle Verknüpfung zwischen dem Onkoprotein Ras und dem Prozess der DNA-Methylierung in der Suppression bestimmter für die Tumorabwehr wichtiger Gene experimentell zu unterstützen.
Conrad, Janine
core   +1 more source

Supplementary Figure 6 from Effective Activity of Cytokine-Induced Killer Cells against Autologous Metastatic Melanoma Including Cells with Stemness Features

, 2013
PDF file - 117K, Expression level of ABCG2 (a), NKG2D ligands MIC A/B (b) and ULBP2 (c) in LV-oct4-eGFP transduced cells.
Elena Giacone (14986952), Maja Todorovic (14986934), Giulia Mesiano (5840726), Loretta Gammaitoni (3987983), Daniela Caravelli (14986949), Maria Giuseppa Volpe (14986943), Alessandro Zaccagna (14986940), Susanna Gallo (14986946), Giovanni Grignani (3987965), Lidia Giraudo (14986931), Franco Picciotto (14986937), Alberto Pisacane (8465721), Antonella Balsamo (14936988), Valeria Leuci (13995509), Ymera Pignochino (3987968), Dario Sangiolo (3987992), Fabrizio Carnevale-Schianca (7872878), Tiziana Venesio (4347988), Massimo Aglietta (3457646)   +18 more
core   +1 more source

Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease

Frontiers in Immunology
IntroductionIt is now clear that coronavirus disease 19 (COVID-19) severity is associated with a dysregulated immune response, but the relative contributions of different immune cells is still not fully understood.
Daniel Fernández-Soto, Álvaro F. García-Jiménez, José M. Casasnovas, Mar Valés-Gómez, Hugh T. Reyburn   +4 more
doaj   +1 more source

Abstract LB-313: Soluble UL16 binding protein 2 is elevated in the sera of lung cancer patients

, 2010
NKG2D ligands are the surface molecules which induce expression on transformed cells. Specifically they bind to NKG2D on NK cells, and this binding induces activation of NK cells.
Jun Kurai, Hiroki Chikumi, Akira Yamasaki, Eiji Shimizu, Naoto Burioka, Tadashi Igishi, Kosuke Yamaguchi, Naoki Kinoshita, Asuka Shimizu, Kiyoshi Hashimoto, Masaki Nakamoto, Shingo Matsumoto, Miyako Takata   +12 more
core   +1 more source

Lentiviral transduction for transfer of chNKG2D.

, 2013
A, antigen-specific enrichment of lentivirally transduced chNKG2Dpos MNCs. On day 13 after transduction the cells were co-cultured either with Ba/F3, ULBP2pos Ba/F3 or without target cells.
Wolfgang Holter (332975), Heinrich Kovar (264581), Yves A. Muller (107938), Florian Full (332968), Adelheid Cerwenka (23169), Peter F. Ambros (224784), Jan Dörrie (285223), Armin Ensser (173680), Ornella Parolini (303400), Gabriel Götz (332965), Julia Proff (308574), Manfred Lehner (332963), Hinrich Abken (107201), Niels Schaft (285224)   +13 more
core   +1 more source

Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine‐induced killer cell efficiency in multiple myeloma via the NKG2D pathway

Clinical & Translational Immunology
Objectives The rapid recognition of epigenetic manipulation's potential in restricting cancer cell capabilities spurred translational initiatives, including histone deacetylase inhibitors (HDACis).
Jingjing Pu, Amit Sharma, Ting Liu, Jian Hou, Ingo GH Schmidt‐Wolf   +4 more
doaj   +1 more source

Ex vivo expansion with ULBP2-TB40 infected DC results in highly functional HCMV-specific CD8+ T cells.

, 2016
(A) Dot plots of an experiment performed with cells from one donor indicating percentage of pp65-specific CD8+ T cells before expansion and after 14 days of co-culture with TB40 or ULBP2-TB40 infected DC.
Mijo Golemac (721297), Suzana Malić (3371861), Peggy Riese (3371846), Stipan Jonjić (3371864), Pavankumar R. Varanasi (492513), Adriana Tomić (3371858), Astrid Krmpotić (3371849), Martin Messerle (139659), Eva M. Borst (3371855), Carlos A. Guzmán (111454), Eva Mischak-Weissinger (3371852)   +10 more
core   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source