Results 71 to 80 of about 2,160 (157)
Loss of ULBP2 on target cells during NK cell-mediated cytolysis.
, 2014 (A, B) NK cell-mediated specific down-regulation of ULBP2. 105 Jurkat (left panels) or H9 cells (right panels) were incubated with (+NK) or without (−NK) in an equal number of IL-2 expanded peripheral blood NK cells at 37°C for 2 hours.
Peter D. Sun (206280) +1 more
core +1 more source
Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
Microorganisms, 2019 An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified.
Eleonora Cimini +12 more
doaj +1 more source
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, Volume 19, Issue 11, Page 3096-3119, November 2025.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.
, 2014 The NKG2D activating receptor on human NK cells mediates "altered self" recognition, as its ligands (NKG2DLs) are upregulated on target cells in a variety of stress conditions.
PAOLINI, Rossella +17 more
core +1 more source
Brain and Behavior, Volume 15, Issue 9, September 2025.This graphical abstract summarizes a Mendelian randomization study exploring the causal relationship between cerebrospinal fluid (CSF) plasma proteins and delirium. 1. Data Sources: The study uses 910 CSF plasma proteins as exposures, sourced from the ONTIME database, and examines their associations with delirium outcomes (non‐induced by alcohol or ...
Zhihui Xu +6 more
wiley +1 more source
Down-regulation of the NKG2D receptor is differentially controlled by MICA and ULBP2 ligands
, 2013 The activating NKG2D receptor on human NK cells mediates “induced self recognition” in that its ligands are up-regulated by stressed or diseased cells.
PAOLINI, Rossella +7 more
core +1 more source
Expression of NKG2D ligands on MM tumor cell lines.
, 2022 The expression of MICA, MICB, ULBP1, ULBP2, ULBP3, ULBP4, ULBP5 and ULBP6 was assessed by flow cytometry with respective antibodies. (PDF)
Yu Yang Ng (12884036) +7 more
core +1 more source
Endoplasmic Reticulum Stress in Cancer
MedComm, Volume 6, Issue 7, July 2025.Persistent ER stress in tumors activates UPR sensors (IRE1α, PERK, ATF6), driving cancer proliferation, metastasis, immune evasion, and drug resistance. This review explores UPR‐mediated signaling crosstalk, angiogenesis, and therapeutic targeting to develop safer anticancer strategies.
Ruixin Zhou +5 more
wiley +1 more source
, 2011 Lola Fernández-Messina ...et al.The activating immune receptor NKG2D binds to multiple stress-induced ligands that are structurally different: MHC-class I-related Chain (MIC) A/B molecules have a transmembrane domain whereas most UL16 binding proteins
Sonia Agüera-González +10 more
core +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source