Results 61 to 70 of about 2,160 (157)

NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors

OncoImmunology, 2016
The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) and UL-16 binding protein (ULBP) family members expressed on tumor cells with the corresponding NKG2D receptor triggers cytotoxic effector functions in NK cells and γδ T ...
Guranda Chitadze, Marcus Lettau, Stefanie Luecke, Ting Wang, Ottmar Janssen, Daniel Fürst, Joannis Mytilineos, Daniela Wesch, Hans-Heinrich Oberg, Janka Held-Feindt, Dieter Kabelitz   +10 more
doaj   +1 more source

P53 Inhibition Diminishes IGSF9 Gene Activity to Promote DNA Repair and Exacerbate the Progression of Colon Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 1, January 2026.
Highlights of the Study: “P53 Inhibition Diminishes IGSF9 Gene Activity to Promote DNA Repair and Exacerbate Progression of Colon Cancer” ABSTRACT Colon cancer (CC) is a malignancy with high global incidence and mortality, and elucidating its underlying molecular mechanisms is critical for improving prognostic assessment and therapeutic strategies.
Huan‐yu Zhang, Dan Tian, Wan‐fu Zhang, Ying‐hui Zhang, Jia‐li Feng, Juan Sheng, Xue‐qin Shang   +6 more
wiley   +1 more source

lncDILC Downregulation in Liver Cancer‐Associated Fibroblasts Drives Pro‐Invasive Conversion via a miR‐6071‐ZNF395 Axis

Cancer Science, Volume 117, Issue 1, Page 145-155, January 2026.
We found in the present study the loss‐of‐function of a sequential inhibitory cascade of lncDILC‐miR‐6071‐ZNF395 in liver CAFs, which promoted the NF‐CAF conversion through increasing expression of pro‐invasive cytokines like IL‐6, LIF, CXCL12, and TGF‐β.
Yawen Li, Jilong Liu, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu, Guoqing Shi, Xuemei Liu   +7 more
wiley   +1 more source

BB-94 abrogates NK cell-induced shedding of ULBP2 from apoptotic cells.

, 2014
(A) BB-94 blocks spontaneous shedding of ULBP2 from Jurkat and H9 cells. 106 Jurkat cells or 5×105 H9 cells were cultured in the presence of DMSO, Z-VAD-FMK and BB-94 for 24 or 48 hours in RPMI-1640 medium with 10% FBS, the resulting cell culture ...
Peter D. Sun (206280), Ruipeng Wang (532683)   +1 more
core   +1 more source

Flavonoids and miRNA Modulation: A Novel Approach to Managing Cancer, Diabetes, Depression, and Neurological Disorders

BioMed Research International, Volume 2026, Issue 1, 2026.
microRNAs (miRNAs) regulate gene expression post‐transcriptionally and play essential roles in various cellular processes. Disruption of their normal expression contributes to the pathogenesis of numerous diseases, including cancer, diabetes, depression, and neurological disorders. Consequently, restoring or inhibiting miRNA function has become a major
Mohadese Mahdie, Sedigheh Momenzadeh, Somayeh Reiisi, Razieh Heidari, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

The spontaneous and NK cell-mediated shedding of ULBP2 from tumor cells.

, 2014
(A, B) Apoptosis-induced shedding of ULBP2 is more intense than spontaneous shedding of it. (A) 2.5×106 Jurkat cells were treated with 2 µg/ml ActD, 4 µM CPT or 20 µM ETO for the indicated time in 0.5 ml serum-free RPMI 1640 medium.
Peter D. Sun (206280), Ruipeng Wang (532683)   +1 more
core   +1 more source

Immune Evasion by CMV and BK Virus: Lurking Viruses Waiting for the Right Moment to Deliver a Fatal Blow to Individuals With Compromised Immunity

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Human cytomegalovirus (CMV) and BK polyomavirus are archetypal latent DNA viruses that establish lifelong persistence and cause severe disease upon reactivation in immunocompromised hosts. Although they differ markedly in virion architecture, genome size, and coding capacity, both viruses converge on a shared biological principle: durable persistence ...
Luobin Robin Zheng, Maike Zheng, Yongqiang Wang, Shijun J. Zheng   +3 more
wiley   +1 more source

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy

Blood Advances, 2018
: Natural killer (NKs) cells provide rapid responses to viral-infected and malignant cells, including acute myeloid leukemia (AML) blasts. The balance among inhibitory and activating signals, delivered by multiple interactions between ligands on target ...
Sara Mastaglio, Eric Wong, Travis Perera, Jane Ripley, Piers Blombery, Mark J. Smyth, Rachel Koldej, David Ritchie   +7 more
doaj   +1 more source

Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
1. Functional impairment of CD59‒ NK cells in PNH is observed, with minimal change in CD59+ NK cells. 2. Direct killing ability of NK cells against target cells is reduced. 3. NK cells weakened T‐cell regulation, leading to hyperfunction of T lymphocytes and contributing to immune escape.
Chaomeng Wang, Yan Yang, Wei Wang, Liyan Li, Mengting Che, Yingying Chen, Honglei Wang, Zhaoyun Liu, Lijuan Li, Hui Liu, Rong Fu   +10 more
wiley   +1 more source

The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

Scandinavian Journal of Immunology, Volume 102, Issue 6, December 2025.
In this study, we found that rs7542235 allele G tags a deletion of the CFHR1 gene. We also found that rs6677604 allele A tags a deletion of the whole CFHR3–1 locus. The plasma proteomics studies show that both variants are associated with an altered expression of FH/FHR proteins thus revealing a novel level of intricate regulation of the complement ...
Salla Markkinen, A. Inkeri Lokki, Ilkka Helanterä, Jarmo Ritari, Jukka Partanen, Seppo Meri, Kati Hyvärinen   +6 more
wiley   +1 more source