Results 51 to 60 of about 2,160 (157)

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, Volume 117, Issue 6, Page 1635-1650, June 2026.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source

Spontaneous shedding of ULBP2 does not result from tumor cell apoptosis.

, 2014
(A, B) Spontaneous shedding of ULBP2 from Jurkat and H9 cells. Jurkat (A) or H9 (B) cells were cultured with initial seeding cell numbers ranging from 0.5×105 to 4×105 cells/ml in 48-well plates, the cells were harvested at various time points (from 17 ...
Peter D. Sun (206280), Ruipeng Wang (532683)   +1 more
core   +1 more source

High‐throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype‐specific serologically relevant biomarkers

Molecular Oncology, 2021
Despite significant advancements in breast cancer (BC) research, clinicians lack robust serological protein markers for accurate diagnostics and tumor stratification.
Thilde Terkelsen, Maria Pernemalm, Pavel Gromov, Anna‐Lise Børresen‐Dale, Anders Krogh, Vilde D. Haakensen, Janne Lethiö, Elena Papaleo, Irina Gromova   +8 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, Volume 20, Issue 3, Page 850-862, March 2026.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Sex Differences in Cancer Immunotherapy—Clinical Evidence and Mechanisms With a Focus on NSCLC

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Accumulating evidence suggests that the immune system shows subtle but relevant differences between men and women. These differences may have an impact on cancer development and TME composition as well as responses to and adverse events elicited by immunotherapies.
Eva Krieghoff‐Henning, Balagopal Pai, Maike Collienne, Isabel Ben‐Batalla, Sonja Loges   +4 more
wiley   +1 more source

A Combined ULBP2 and SEMA5A Expression Signature as a Prognostic and Predictive Biomarker for Colon Cancer [PDF]

, 2017
Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable.
Musa Akoglu, ISBILEN, M, Murat Isbilen, GONEN, MÜBECCEL SARA, NISSAN, A, Aviram Nissan, AKOGLU, M, Erdal Birol Bostanci, DAYANC, BE, BOSTANCI, EMİNE ÖZLEM, OZYERLI, E, GOMCELI, I, Secil Demirkol, Ismail Gomceli, TURHAN, NİHAN, Nesrin Turhan, KONU, O, Sevi Durdu, Ali Osmay Gure, Demirkol, SEÇİL, GURE, AO, Mesut Tez, Ozlen Konu, Ezgi Ozyerli, DURDU, S, Baris Emre Dayanc, TEZ, M, Mithat Gonen, Isbilen, Murat, Gonen, Mithat, Dayanc, Baris Emre, Turhan, Nesrin, Bostanci, Erdal Birol, Konu, Ozlen, Gomceli, Ismail, Ozyerli, Ezgi, Nissan, Aviram, Gure, Ali Osmay, Akoglu, Musa, Durdu, Sevi, Tez, Mesut   +40 more
core   +3 more sources

Genomic organization and evolution of the ULBP genes in cattle

BMC Genomics, 2006
Background The cattle UL16-binding protein 1 (ULBP1) and ULBP2 genes encode members of the MHC Class I superfamily that have homology to the human ULBP genes. Human ULBP1 and ULBP2 interact with the NKG2D receptor to activate effector cells in the immune
Lewin Harris A, Roe Bruce A, Beever Jonathan E, Marron Brandy M, Larson Joshua H   +4 more
doaj   +1 more source

Flavones and Aminoflavones Increase the Cytotoxicity of NK Cells in Human Non‐Small Cell Lung Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Natural flavonoids (flavones) and synthetic aminoflavones are known for their anti‐cancer properties; however, their immunomodulation ability has been largely unexplored. This study determined that synthetic flavones and aminoflavones modulate the cytotoxicity of natural killer (NK) cells against lung cancer cells.
Ping‐Chih Hsu, Chih‐Cheng Chien, Yang‐Je Cheng, Chuan‐Hsin Chang, Tzenge‐Lien Shih   +4 more
wiley   +1 more source

BB-94 rescues cell surface expression of ULBP2 in apoptotic cells.

, 2014
(A, B) BB-94 abrogates apoptotic compound-induced shedding of ULBP2. (A) Jurkat cells were treated with 2 µg/ml Act D, 4 µM CPT or 20 µM ETO for 4 hours in the presence or absence of BB-94. The treated cells were stained by PE-conjugated mouse anti-human
Peter D. Sun (206280), Ruipeng Wang (532683)   +1 more
core   +1 more source

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation.

PLoS Pathogens, 2014
NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A ...
Ceri A Fielding, Rebecca Aicheler, Richard J Stanton, Eddie C Y Wang, Song Han, Sepehr Seirafian, James Davies, Brian P McSharry, Michael P Weekes, P Robin Antrobus, Virginie Prod'homme, Fabien P Blanchet, Daniel Sugrue, Simone Cuff, Dawn Roberts, Andrew J Davison, Paul J Lehner, Gavin W G Wilkinson, Peter Tomasec   +18 more
doaj   +1 more source