Results 31 to 40 of about 2,160 (157)

ULBP2 in cancer: ligand state, immune regulation, and therapeutic targeting

Frontiers in Immunology
UL16-binding protein 2 (ULBP2) is a stress-inducible NKG2D ligand whose expression has been linked to both tumor recognition and poor clinical outcomes. These observations are difficult to interpret from expression measurements alone.
Jiarun Liu, Jiarun Liu, Xiaohuan Wang, Junlin Chen, Xinyu Wang, Xuning Wang, Yongqi Shan   +6 more
doaj   +1 more source

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.

PLoS Pathogens, 2016
Development of an effective vaccine against human cytomegalovirus (HCMV) is a need of utmost medical importance. Generally, it is believed that a live attenuated vaccine would best provide protective immunity against this tenacious pathogen.
Adriana Tomić, Pavankumar R Varanasi, Mijo Golemac, Suzana Malić, Peggy Riese, Eva M Borst, Eva Mischak-Weissinger, Carlos A Guzmán, Astrid Krmpotić, Stipan Jonjić, Martin Messerle   +10 more
doaj   +1 more source

BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis

Journal for ImmunoTherapy of Cancer, 2020
Background Targeted therapies and immunotherapies are first-line treatments for patients with advanced melanoma. Serine–threonine protein kinase B-RAF (BRAF) and mitogen-activated protein kinase (MEK) inhibition leads to a 70% response rate in patients ...
Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard   +11 more
doaj   +1 more source

An Immunosensor for the Detection of ULBP2 Biomarker

, 2022
Pancreatic cancer (PC) is a global health problem that features a very high mortality rate. The UL16 binding protein 2 (ULBP2) is a new biomarker for PC detection.
Pei-Yi Chu, Congo Tak-Shing Ching, Su-Yu Liao, Thien Luan Phan, Wen-Chi Yang, Nguyen Van Hieu, Hsing-Ju Wu, Kang-Ming Chang, Chin-Chang Yi   +8 more
core  

Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity

, 2020
Fumarate is a tricarboxylic acid cycle metabolite whose intracellular accumulation is linked to inflammatory signaling and development of cancer. In this study, we demonstrate that endogenous fumarate accumulation upregulates surface expression of the ...
Jepsen, Stine Dam, Møller, Sofie Hedlund, Skov, Søren, Droujinine, Alec, Høgh, Rikke Illum, Mellergaard, Maiken, Andresen, Lars   +6 more
core   +1 more source

Inhibition of ULBP2 loss by apoptotic inhibitor.

, 2014
(A) Z-VAD-FMK inhibited apoptotic compound-induced loss of cell surface ULBP2 in Jurkat cells. Jurkat cells were pretreated with 50 µM Z-FA-FMK (dotted lines) or Z-VAD-FMK (solid lines) for 30 min, and then were treated with 2 µg/ml ActD, 4 µM CPT or 20 ...
Peter D. Sun (206280), Ruipeng Wang (532683)   +1 more
core   +1 more source

The mIRNA519a-3p and NKG2D in endometriosis.

Indonesian Journal of Obstetrics and Gynecology, 2022
Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms.
Cepi Teguh Pramayadi, Muharam Natadisastra, Kanadi Sumapradja, Aria Kekalih   +3 more
doaj   +1 more source

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone

Frontiers in Cell and Developmental Biology, 2022
Background: Paget’s disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity.
Ilhame Diboun, Ilhame Diboun, Sachin Wani, Stuart H. Ralston, Omar M. E. Albagha, Omar M. E. Albagha   +5 more
doaj   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60

, 2015
Copyright © 2015 by The American Association of Immunologists, Inc. Many malignant cells release the NKG2D ligand ULBP2 from their cell surface to evade immunosurveillance by NK cells and CD8 T cells.
Li, Ying, Bouck, David, Chen, Taosheng, Sullivan, Erin, Wendt, Susanne, Leung, Wai Hang, Leung, Wing, Vong, Queenie P., Lin, Wenwei, Bari, Rafijul   +9 more
core   +1 more source