Results 41 to 50 of about 2,160 (157)
Frontiers in Immunology, 2017 Natural killer cells (NK) are essential for the elimination of resistant acute myeloid and acute lymphoblastic leukemia (AML and ALL) cells. NK cell-based immunotherapies have already successfully entered for clinical trials, but limitations due to ...
Stephan Kloess +9 more
doaj +1 more source
PLoS ONE, 2023 The immune system plays a central role in the onset and progression of cancer. A better understanding of transcriptional changes in immune cell-related genes associated with cancer progression, and their significance in disease prognosis, is therefore ...
Alberto D'Angelo +20 more
doaj +1 more source
European Journal of Immunology, Volume 56, Issue 10, October 2026.Differential secretion mechanisms and predicted structural flexibility are described as additional effects of MICA polymorphism in the immune response. Structural features might explain impaired antibody recognition of certain MICA alleles, supporting that MICA genotyping should be considered in biomarker studies and NKG2D‐based therapeutic development.
Silvia López‐Borrego +5 more
wiley +1 more source
, 2014 Soluble ULBP2 is a marker for poor prognosis in several types of cancer. In this study we demonstrate that both soluble and cell surface-bound ULBP2 is transported via a so far unrecognized endosomal pathway.
Hagemann-Jensen, Michael Henrik +5 more
core +1 more source
Novel immune-related prognostic model and nomogram for breast cancer based on ssGSEA
Frontiers in Genetics, 2023 This study aimed to construct an immune-related prognostic model and a nomogram to predict the 1-, 3-, and 5-year overall survival (OS) of breast cancer patients.
Linrong Li +4 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.
Seongwan Kim +2 more
wiley +1 more source
Independent prognostic genes and mechanism investigation for colon cancer
Biological Research, 2018 Propose We aimed to explore the potential molecular mechanism and independent prognostic genes for colon cancer (CC). Methods Microarray datasets GSE17536 and GSE39582 were downloaded from Gene Expression Omnibus.
Chunsheng Li +3 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: CD8+ T cells, a critical component of the tumor immune microenvironment, have become a key target of cancer immunotherapy. Considering the deficiency of robust biomarkers for head and neck squamous cell carcinoma (HNSCC), this study aimed at ...
Shoujing Zhang, Wenyi Zhang, Jian Zhang
doaj +1 more source
Frontiers in Genetics, 2021 Numerous researches have focused on the genetic variations affecting SARS-CoV-2 infection, whereas the epigenetic effects are inadequately described. In this report, for the first time, we have identified potential candidate genes that might be regulated
Jibran Sualeh Muhammad +8 more
doaj +1 more source
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, Volume 7, Issue 4, August 2026.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source