Results 21 to 30 of about 2,160 (157)

Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer

open access: yesFrontiers in Immunology, 2023
BackgroundThe poor clinical accuracy to predict the survival of colon cancer patients is associated with a high incidence rate and a poor 3-year survival rate.
Zhen Ye   +4 more
doaj   +1 more source

A prognostic model for cervical cancer based on ferroptosis-related genes

open access: yesFrontiers in Endocrinology, 2022
BackgroundFerroptosis is widely involved in the occurrence and development of various cancers, but a specific mechanism involving ferroptosis in cervical cancer is still unclear.MethodsBased on the expressions of ferroptosis-related genes, a prognostic ...
Huijun Du   +12 more
doaj   +1 more source

ULBP2 is differentially expressed in central nervous system metastasis in human breast cancer.

open access: yes, 2023
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with ...
Shahan Mamoor
core   +1 more source

Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. [PDF]

open access: yesPLoS Pathogens, 2010
The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related ligands.
Steffen Müller   +3 more
doaj   +1 more source

The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

open access: yeseLife, 2016
Expression of the stress-induced ligands MICA, MICB and ULBP 1–6 are up-regulated as a cellular response to DNA damage, excessive proliferation or viral infection; thereby, they enable recognition and annihilation by immune cells that express the ...
Dominik Schmiedel   +5 more
doaj   +1 more source

Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D

open access: yesViruses, 2020
The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses.
Mohammad Diab   +4 more
doaj   +1 more source

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

open access: yesNeoplasia: An International Journal for Oncology Research, 2012
Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer.
Xiaosong Wu   +4 more
doaj   +1 more source

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

open access: yeseLife, 2022
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion.
Ceri Alan Fielding   +20 more
doaj   +1 more source

CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

open access: yesOncoImmunology, 2022
NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands ...
Meng Liu   +12 more
doaj   +1 more source

ULBP2-TB40 infected cells have lower MHC class I surface expression than TB40 infected cells.

open access: yes, 2016
(A,B) Representative plots showing HLA class I expression using pan-HLA-A,B,C antibody (HLA I) or HLA-A02:01 antibody labeling of infected (IE1/2+) DC.
Mijo Golemac (721297)   +10 more
core   +1 more source

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