Results 1 to 10 of about 2,160 (157)

Resveratrol Contributes to NK Cell-Mediated Breast Cancer Cytotoxicity by Upregulating ULBP2 Through miR-17-5p Downmodulation and Activation of MINK1/JNK/c-Jun Signaling [PDF]

Frontiers in Immunology
BackgroundsNatural killer (NK) cell mediated cytotoxicity is a crucial form of anti-cancer immune response. Natural killer group 2 member D (NKG2D) is a prominent activating receptor of NK cell.
Ling-Bo Qian
exaly   +6 more sources

An Immunosensor for the Detection of ULBP2 Biomarker

Micromachines, 2020
Pancreatic cancer (PC) is a global health problem that features a very high mortality rate. The UL16 binding protein 2 (ULBP2) is a new biomarker for PC detection.
Pei-Yi Chu, Congo Tak-Shing Ching, Kang-Ming Chang   +2 more
exaly   +5 more sources

Ectopic ULBP2 Is Associated with Decreased NKG2D Expression in CD8⁺ T Cells Under T Cell-Modulatory Conditions in a Murine Tumor Model. [PDF]

Cells
UL16-binding protein 2 (ULBP2), a ligand for the activating receptor NKG2D, plays a dual role in tumor immunity, promoting immune activation or suppression, depending on the context. To investigate its impact on CD4+CD25+ T cell-targeted immunotherapies,
Teruya Y, Yamaguchi K, Yamane K, Miyake N, Nakayama Y, Nonaka T, Chikumi H, Yamasaki A.   +7 more
europepmc   +3 more sources

An Immune-Related Prognostic Gene ULBP2 Is Correlated With Immunosuppressive Tumor Microenvironment and Immunotherapy in Breast Cancer [PDF]

Heliyon
Breast cancer (BC) is one of the major dangerous tumors threatening women's lives. We here aimed to sort out prognostic immune-related genes by univariate Cox regression analysis and build a model of immune-related genes for forecasting the prognosis of ...
Guosheng Ren, Jiazhou Liu
exaly   +4 more sources

METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer. [PDF]

Hereditas
Background Cervical cancer (CC) is one of the most prevalent malignancies in women, posing a significant challenge globally. However, the precise molecular mechanism regulating CC progression through methyltransferase-like protein 3 (METTL3) and UL16 ...
Ren H, Wang Y, Yu J, An L, Ma X, Pan J.
europepmc   +2 more sources

ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation. [PDF]

Cell Death Dis
Gastric cancer (GC) is characterised by a dense stromal microenvironment, lack of therapeutic targets, and limited effective treatment options, collectively leading to a poor prognosis.
Zhang W, Ren W, Guo S, Han H, Cai W, Bai H, Li L, Jiang X, Zheng X, Zhang T, Wang Y, Ye H, Cao H, Shi W, Zhou H, Yu Z, Qin L, Jiao Z.   +17 more
europepmc   +2 more sources

Insights Into Functional Amino Acids of ULBP2 as Potential Immunogens Against Cancer

Scientific African, 2020
The ability of Natural Killer (NK) cells to eliminate cancerous cells is largely dependant on the activation of the stimulatory or co-stimulatory natural killer group 2, member D (NKG2D) receptor.
Tayo Alex Adekiya, Paul Chukwudi Ikwegbue, Raphael Taiwo Aruleba   +2 more
exaly   +3 more sources

Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease. [PDF]

Tumour Virus Res
To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes.
Robinson E, Rodriguez I, Argueta V, Xie Y, Lou H, Milano R, Lee HJ, Burdett L, Mishra SK, Yeager M, Mirabello L, Dean M, Orozco R.   +12 more
europepmc   +2 more sources

Impaired immune reconstitution in HIV infection: the role of CD4⁺ T-cell-associated NKG2D ligands, CD4⁺ T-cell subsets imbalance, and immune function deficiency. [PDF]

Front Immunol
ObjectiveThe role of natural killer (NK) cells, which mediate innate immunity, in the immune reconstitution of people living with HIV (PLWH) remains unclear.
Xu Q, Zhang Q, Xu P, Zhang T, Wu H, Zhang X, Moog C, Su B.   +7 more
europepmc   +2 more sources

Breast cancer bone metastasis and bone metastatic cells retain NKG2DLs intracellularly: could this be a strategy to evade immune recognition? [PDF]

Front Cell Dev Biol
Bone metastases dramatically worsen breast cancer (BC) prognosis reducing overall survival. Natural killer (NK) cells recognize and eliminate malignant cells through the interaction with NKG2D receptor ligands (NKG2DLs) on cancer cells.
Gomarasca M, Maroni P, Verdelli C, Gerosa L, Faraldi M, Luzzati A, Cannavò L, Banfi G, Lombardi G.   +8 more
europepmc   +2 more sources