ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity [PDF]
International Journal of Molecular SciencesUL-16 binding protein 2 (ULBP2), a human NKG2D ligand, has been identified as a poor prognostic factor in several cancers based on recent comprehensive analyses of immune-related genes using the Cancer Genome Atlas datasets.
Akira Yamasaki +2 more
exaly +3 more sources
Natural killer cell-mediated shedding of ULBP2. [PDF]
PLoS ONE, 2014 UL16 binding proteins (ULBPs) are a family of cell surface proteins that are present in transformed and stressed cells and ligands for NKG2D. Soluble NKG2D ligands have been found in sera from cancer patients with their protein concentrations correlated ...
Ruipeng Wang, Peter D Sun
doaj +2 more sources
Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection.
PLoS ONE, 2011 BackgroundTo discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled.
Ya-Ting Chang +11 more
doaj +2 more sources
European Journal of Volunteering and Community-Based Projects, 2021 The Natural killer (NK) cells' ability to destroy cancerous cells is predominantly focused on the activation of the co-stimulatory and natural killer group two with receptor of member-D also called NKGD2/NKG2D.
Muhammad Mazhar Fareed +3 more
doaj +5 more sources
Epigenetic modulation elicits an NK cell-mediated immune response in urothelial carcinoma. [PDF]
Mol MedUrothelial carcinoma (UC), the second most prevalent cancer of the urothelial system, has demonstrated a well-developed ability to evade natural killer (NK) cell-mediated killing via various pathways, highlighting the need for innovative therapeutic ...
Kumari H +13 more
europepmc +2 more sources
Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase. [PDF]
Front ImmunolBackgroundThe SARS-CoV-2 Omicron variant is associated with milder COVID-19 symptoms than previous strains. This study analyzed alterations in natural killer (NK) cell-associated immunity dynamics in mild and moderate COVID-19 cases during the Omicron ...
Nishikawa Y +19 more
europepmc +2 more sources
Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism. [PDF]
Nat CommunVenous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases.
Kong Y +9 more
europepmc +2 more sources
A Multi-Targeting Chimeric Antigen Receptor-T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non-Small Cell Lung Cancer. [PDF]
Adv Sci (Weinh)A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Wang L +8 more
europepmc +2 more sources
HCMV Variants Expressing ULBP2 Enhance the Function of Human NK Cells via Its Receptor NKG2D [PDF]
European Journal of ImmunologyLars Steinbrück +2 more
exaly +2 more sources
RUNX regulated immune-associated genes predicts prognosis in breast cancer
Frontiers in Genetics, 2022 Background: Breast cancer is the most common malignant tumor in women. RUNX family has been involved in the regulation of different carcinogenic processes and signaling pathways with cancer, which is closely related to immunity and prognosis of various ...
Jingyue Fu +6 more
doaj +1 more source