Results 91 to 100 of about 20,424,840 (239)

Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer [PDF]

, 2019
International audienceHighlights •MRT is a form of synchrotron generated X-ray radiosurgery dedicated to brain tumours. •Normal tissue tolerates high X-ray dose thanks through lattice of microbeams. •MRT operates at very high dose rate (kGy·s−1)
Bräuer-Krisch, Elke, Djonov, Valentin, Serduc, Raphaël, Eling, Laura, Balosso, Jacques, Laissue, Jean, Adam, Jean Francois, Bouchet, Audrey Michele, Nemoz, Christian, Bouchet, Audrey, Laissue, Jean, A., Adam, Jean-François, Bouchet A, Bräuer-Krisch E, Adam JF, Djonov V, Eling L, Serduc R, Nemoz C, Laissue J, Balosso J   +20 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Long-term toxicity and efficacy of FLASH radiotherapy in dogs with superficial malignant tumors

Frontiers in Oncology
IntroductionFLASH radiotherapy (RT) has emerged as a promising modality, demonstrating both a normal tissue sparing effect and anticancer efficacy. We have previously reported on the safety and efficacy of single fraction FLASH RT in the treatment of ...
Bolette W. Gjaldbæk, Maja L. Arendt, Elise Konradsson, Kristine Bastholm Jensen, Sven Å. J. Bäck, Per Munck af Rosenschöld, Crister Ceberg, Kristoffer Petersson, Kristoffer Petersson, Betina Børresen   +9 more
doaj   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Ultra-high dose rate radiobiological effects: Laser-driven radiation sources as complementary research tools

Ultra-high dose-rate radiotherapy and the observation of the so-called FLASH effect have stimulated renewed interest in how the temporal structure of dose delivery influences the biological response to ionizing radiation.

core   +1 more source

Carbon ion FLASH irradiation reduces acute skin toxicity compared with conventional dose rate irradiation

Scientific Reports
FLASH radiotherapy, defined by ultra-high dose rates exceeding 40 Gy/s, has shown potential for widening the therapeutic window due to its demonstrated normal tissue-sparing effects while maintaining tumor control with electrons, photons, and protons ...
Yukari Yoshida, Hiromu Suda, Mutsumi Tashiro, Ken Yusa, Masao Nakao, Koichi Ando, Akihisa Takahashi, Tatsuya Ohno   +7 more
doaj   +1 more source

Self‐Cleaning Sensor Surfaces for Long‐Term Environmental Monitoring

Advanced Engineering Materials, EarlyView.
Long‐term use of unattended outdoor sensors without soiling or biofouling is achieved through generation of a micro‐ and nanorough cuvette surface by combing hydrophobic nanoparticles with fluorinated polymers, crosslinked and surface‐attached through CHic chemistry. The coating demonstrates self‐cleaning behavior and prolonged outdoor stability, which
Sanam Kumari Rajak, Yasmina Frey, Ulrike Wallrabe, Oswald Prucker, Jürgen Rühe   +4 more
wiley   +1 more source

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source

Establishing an Electron FLASH Platform for Preclinical Research in Low-Resource Settings

Radiation
Background: FLASH radiotherapy delivers ultra-high dose rates with normal tissue sparing, but mechanisms remain unclear. We present a streamlined workflow for establishing a LINAC-based electron FLASH (eFLASH) platform in low-resource settings without ...
Banghao Zhou, Lixiang Guo, Weiguo Lu, Mahbubur Rahman, Rongxiao Zhang, Varghese Anto Chirayath, Yang Kyun Park, Strahinja Stojadinovic, Marvin Garza, Ken Kang-Hsin Wang   +9 more
doaj   +1 more source