Results 101 to 110 of about 117,639 (239)

IN VITRO FLASH EFFECT AS A FUNCTION OF ULTRA-HIGH DOSE RATES WITH PROTON BEAM

International Journal of Particle Therapy
Radiotherapy at ultra-high dose rates (UHDR, >50 Gy/s) is rapidly gaining attention thanks to its sparing of healthy tissues and unaltered tumor control (FLASH effect). However, the mechanisms of FLASH remain unclear. In particular, little data is available at even higher dose rates and thus its potential therapeutic benefits remain unknown. In this
Temelie, Mihaela, Sitarz, Mateusz, Tudor, Mihaela, Lecrosnier, Kilian, Radu, Mihai, Savu, Diana, Chevalier, François   +6 more
openaire   +2 more sources

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, EarlyView.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source

Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform

Precision Radiation Oncology
Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes.
Fada Guan, Dadi Jiang, Xiaochun Wang, Ming Yang, Kiminori Iga, Yuting Li, Lawrence Bronk, Julianna Bronk, Liang Wang, Youming Guo, Narayan Sahoo, David R. Grosshans, Albert C. Koong, Xiaorong R. Zhu, Radhe Mohan   +14 more
doaj   +1 more source

Metrology for advanced radiotherapy using particle beams with ultra-high dose rates

Physics in Medicine & Biology
Abstract Dosimetry of ultra-high dose rate beams is one of the critical components which is required for safe implementation of FLASH radiotherapy (RT) into clinical practice. In the past years several national and international programmes have emerged with the aim to address some of the needs that are required for translation of this ...
Anna Subiel, Alexandra Bourgouin, Rafael Kranzer, Peter Peier, Franziska Frei, Faustino Gomez, Adrian Knyziak, Celeste Fleta, Claude Bailat, Andreas Schüller   +9 more
openaire   +4 more sources

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

First experimental validation of silicon-based sensors for monitoring ultra-high dose rate electron beams

Frontiers in Physics
Monitoring Ultra-High Dose Rate (UHDR) beams is one of the multiple challenges posed by the emergent FLASH radiotherapy. Technologies (i.e., gas-filled ionization chambers) nowadays used in conventional radiotherapy are no longer effective when applied ...
Elisabetta Medina, Elisabetta Medina, Arianna Ferro, Arianna Ferro, Mohammad Abujami, Mohammad Abujami, Aurora Camperi, Matteo Centis Vignali, Emanuele Data, Emanuele Data, Damiano Del Sarto, Damiano Del Sarto, Umberto Deut, Umberto Deut, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino, Mohammad Fadavi Mazinani, Marco Ferrero, Veronica Ferrero, Simona Giordanengo, Oscar A. Martì Villarreal, Mohammad Amin Hosseini, Mohammad Amin Hosseini, Felix Mas Milian, Felix Mas Milian, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Diango M. Montalvan Olivares, Diango M. Montalvan Olivares, Marco Montefiori, Marco Montefiori, Giovanni Paternoster, Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Valentina Sola, Valentina Sola, Roberto Cirio, Roberto Cirio, Roberto Sacchi, Roberto Sacchi, Anna Vignati, Anna Vignati   +46 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Corrigendum: Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Frontiers in Oncology, 2020
Joseph D. Wilson, Ester M. Hammond, Geoff S. Higgins, Kristoffer Petersson, Kristoffer Petersson   +4 more
doaj   +1 more source

Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron–Positron Collider (CEPC)

Journal of Synchrotron Radiation
The Circular Electron–Positron Collider (CEPC) in China can also work as an excellent powerful synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field as it
Junyu Zhang, Xiangyu Wu, Pengyuan Qi, Jike Wang   +3 more
doaj   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source