Results 201 to 210 of about 117,639 (239)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Ultra-high dose rate (FLASH) carbon ion irradiation inhibited immune suppressive protein expression on Pan02 cell line. [PDF]

J Radiat Res
Katsuki S, Minami K, Oniwa K, Yagi M, Shimizu S, Hamatani N, Takashina M, Kanai T, Ogawa K.   +8 more
europepmc   +1 more source

Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends Upon Baseline Tissue Oxygenation. [PDF]

Int J Radiat Oncol Biol Phys
Sunnerberg JP, Tavakkoli AD, Petusseau AF, Daniel NJ, Sloop AM, Schreiber WA, Gui J, Zhang R, Swartz HM, Hoopes PJ, Gladstone DJ, Vinogradov SA, Pogue BW.   +12 more
europepmc   +1 more source

Electron beam response corrections for an ultra-high-dose-rate capable diode dosimeter. [PDF]

Med Phys
Dai T, Sloop AM, Schönfeld A, Flatten V, Kozelka J, Hildreth J, Bill S, Sunnerberg JP, Clark MA, Jarvis L, Pogue BW, Bruza P, Gladstone DJ, Zhang R.   +13 more
europepmc   +1 more source

Intracellular Oxygen Transient Quantification in Vivo During Ultra-High Dose Rate FLASH Radiation Therapy. [PDF]

Int J Radiat Oncol Biol Phys
Petusseau AF, Clark M, Bruza P, Gladstone D, Pogue BW.   +4 more
europepmc   +1 more source

ELUCIDATION OF THE MECHANISMS UNDERLYING ULTRA-HIGH DOSE RATE IRRADIATION

ELUCIDATION OF THE MECHANISMS UNDERLYING ULTRA-HIGH DOSE RATE IRRADIATION
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Ultra‐high dose rate FLASH radiation therapy for cancer

Medical Physics, 2023
AbstractConformality has been a key requirement in radiation therapy for cancer to minimize normal tissue toxicity while maintaining tumor control. Since 2014, there has been great interest in ultra‐high dose rate (UHDR), “FLASH,” radiation therapy to enhance this therapeutic window.
Michele M, Kim, Wei, Zou
openaire   +2 more sources

Ultra-high dose-rate proton FLASH improves tumor control

Radiotherapy and Oncology, 2023
Proton radiotherapy (PRT) offers potential benefits over other radiation modalities, including photon and electron radiotherapy. Increasing the rate at which proton radiation is delivered may provide a therapeutic advantage. Here, we compared the efficacy of conventional proton therapy (CONVpr) to ultrahigh dose-rate proton therapy, FLASHpr, in a mouse
Samriddhi Shukla, Taniya Saha, Nihar Rama, Anusha Acharya, Tien Le, Fenghua Bian, Johnny Donovan, Lin Abigail Tan, Ralph Vatner, Vladimir Kalinichenko, Anthony Mascia, John P. Perentesis, Tanya V. Kalin   +12 more
openaire   +2 more sources

FLASH ultra-high dose rates in radiotherapy: preclinical and radiobiological evidence

International Journal of Radiation Biology, 2021
Flash radiotherapy (FLASH-RT) is currently being regarded as the next breakthrough in radiation treatment of cancer, delivering ultrahigh radiation doses in a very short time, and sparing normal tissues from detrimental injury. Here we review the current evidence on the preclinical findings as well as the radiobiological mechanisms underlying the FLASH
Borghini A., Vecoli C., Labate L., Panetta D., Andreassi M., Gizzi L. A.   +5 more
openaire   +2 more sources

Ultra-high Dose-rate Effects in Radiosensitive Bacteria

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1969
(1969). Ultra-high Dose-rate Effects in Radiosensitive Bacteria. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 14, No. 6, pp. 573-575.
T L, Phillips, B R, Worsnop
openaire   +2 more sources